 | | Vol. 11.06 – 14 February, 2023 |
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| The authors showed that IL-23 induced IL-17A only in MAIT cells, possibly contributing to the incomplete penetrance of chronic mucocutaneous candidiasis in patients unresponsive to IL-23. By contrast, IL-23 was required for both baseline and Mycobacterium-inducible IFN-γ immunity in both Vδ2+ γδ T and MAIT cells.
[Science Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To improve the response rate and reverse immunosuppression, scientists combined D2C7-IT tumor cell killing with αCD40 costimulation of antigen-presenting cells. These promising preclinical data allowed for the initiatiation of a Phase I study with D2C7-IT+αhCD40 in patients with malignant glioma.
[Science Translational Medicine] |
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| Researchers report a cooperative Nano-CRISPR scaffold that utilized a specific sgRNA, selected from a functional screen for triggering endogenous GDSME expression, while releasing cisplatin to initiate immunologic cell death.
[Nature Communications] |
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| The authors performed single-cell V(D)J- and RNA-seq on sorted B cells from the colon of healthy individuals and patients with ulcerative colitis.
[Journal Of Experimental Medicine] |
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| Endogenous ouabain, an adrenergic hormone, was elevated in patients with non–small cell lung cancer, and was closely related to tumor pathological stage, metastasis, and survival.
[Science Advances] |
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| Ex vivo flow cytometry was performed on post-mortem blood, cerebrospinal fluid, meninges and white matter from 28 multiple sclerosis and 10 control brain donors to characterize B cells and antibody-secreting cells.
[Ebiomedicine] |
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| To specifically direct NK cells towards tumor cells, researchers developed oncolytic measles vaccines encoding bispecific killer engagers targeting CD16A on NK cells and carcinoembryonic antigen as a model tumor antigen.
[Cell Death & Disease] |
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| Investigators studied an intelligent nanocomposite polymer immunomodulator, drug-free polypyrrole-polyethyleneimine nanozyme (PPY-PEI NZ), which effectively suppressed B cell colony-like growth in vitro accompanied by cytotoxicity via apoptosis induction.
[Biomedicine & Pharmacotherapy] |
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| To enhance a previously designed an oncolytic adenovirus, the authors increaseed the IgG1 Fc-effector mechanisms of the IgGA Fc-fusion peptide, by adding four somatic mutations that increased natural killer cell activation.
[Molecular Therapy Oncolytics] |
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Scientists review the clinical experience with self-replicating RNA-based cancer vaccines, and recent safety data from a study combining a viral replicon particles encoding HER2 plus an anti-PD1 monoclonal antibody.
[Cancer Gene Therapy] |
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| Valo Therapeutics Oy announced it has secured funding of approximately EUR 2.23 million from the European Innovation Council to progress the company’s PeptiCHIP technology, which rapidly identifies a tumor’s antigen presentation profile to drive development of novel personalized immunotherapies.
[Valo Therapeutics Oy] |
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| April 11 – 12, 2023
New York, New York, United States |
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| | The University of Konstanz – Konstanz, Germany |
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| | King’s College London – London, England, United Kingdom |
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| | STEMCELL Technologies – Oxford, England, United Kingdom |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | The International Institute of Molecular and Cell Biology – Warsaw, Poland |
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