 | | Vol. 11.07 – 21 February, 2023 |
| |
|
|
| Scientists characterized a case of long-term HIV-1 remission of a 53-year-old male who was carefully monitored for more than 9 years after allogeneic CCR5Δ32/Δ32 hematopoietic stem cell transplantation performed for acute myeloid leukemia.
[Nature Medicine] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors demonstrated that CD5-expressing dendritic cells helped to prime T cell responses against melanoma, and were associated with survival in human patients and with immune rejection of tumors in mouse models.
[Science] |
|
|
|
| Researchers found that MTSS I-BAR domain containing 1 (MTSS1) was downregulated in lung adenocarcinoma, leading to PD-L1 upregulation, impairment of CD8+ lymphocyte function, and enhanced tumor progression.
[Cell Discovery] |
|
|
|
| Metabolome and transcriptome analyses of human and mouse glioblastoma tumors identified that phosphoglycerate dehydrogenase (PHGDH) expression and serine metabolism were preferentially altered in tumor endothelial cells.
[Cell Metabolism] |
|
|
|
| Scientists uncovered the intricate interactions between recruited innate immune cells and resident astrocytes in the brain metastatic niche that facilitate metastasis of melanoma and breast cancer.
[Nature Cancer] |
|
|
|
| The double-blind randomized trial enrolled 105 healthy HIV-uninfected adults who received three doses of either a trivalent global mosaic, a group M consensus, or a natural clade B gp160 env DNA vaccine, followed by two doses of a heterologous modified vaccinia Ankara–vectored HIV-1 vaccine or placebo.
[Journal Of Clinical Investigation] |
|
|
|
| Researchers showed that indoleamine 2,3-dioxygenase 1 (IDO1) inhibition led to an adverse protection of melanoma cells to T cell-derived interferon-gamma. RNA sequencing and ribosome profiling showed that IFNγ shut down general protein translation, which was reversed by IDO1 inhibition.
[Cell Reports Medicine] |
|
|
|
| Investigators developed a novel therapeutic modality to direct complement activity to the surface of HIV-1-infected cells. The bispecific complement engager was comprised of a nanobody recruiting the complement-initiating protein C1q, and single-chain variable fragments of broadly neutralizing antibodies targeting the HIV-1 envelope protein.
[EMBO Molecular Medicine] |
|
|
|
| In vivo genome-wide CRISPR-Cas9 screening revealed that loss of interferon-induced transmembrane protein 1 (IFITM1) promoted brain colonization of human lung cancer cells.
[EMBO Journal] |
|  |
|
|
|
| Investigators outline key advances in the field of antibody-based therapy with a particular focus on recent and emerging classes of engineered antibody therapeutic candidates, discuss molecular structure and mechanisms of action, and provide updates on clinical development and practice.
[Nature Cancer] |
|
|
|
| The authors explore the mechanisms by which the brain tumor microenvironment suppresses NK cell mediated tumor control, and the methods being used to create NK cell products that subvert immune suppression.
[Npj Precision Oncology] |
|
|
|
|
| Dr. Aleksandar Obradovic is the grand prize winner of the 2023 Michelson Philanthropies & Science Prize for Immunology for his work on developing an individually tailored, cell-specific approach to treating cancer by combining drug treatments with immune-response therapeutics.
[American Association for the Advancement of Science] |
|
|
|
| The FDA will soon require researchers and companies seeking approval for late-stage clinical trials to submit a plan for ensuring diversity among trial participants.
[Nature News] |
|
|
|
|
| March 5 – 9, 2023
Banff, Alberta, Canada |
|
|
|
|
|
| | The University of Melbourne – Melbourne, Australia |
|
|
|
| | National University of Singapore – Singapore, Singapore |
|
|
|
| | Harvard Medical School – Boston, Massachusetts, United States |
|
|
|
| | Helmholtz Centre for Infection Research – Braunschweig, Germany |
|
|
|
| | The University of Konstanz – Konstanz, Germany |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
