 | | | Vol. 11.08 – 28 February, 2023 |
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| To investigate the mechanisms underlying autoimmune susceptibility, researchers mapped the soluble and cellular immune landscape of individuals with Down’s Syndrome.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using 3D immune-stem cell organoids, single-cell analysis of human emphysema lungs, and studies in murine models, the authors investigated aberrant tissue-immune interactions in emphysema.
[Immunity] |
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| Scientists identified a previously uncharacterized immune subset, referred to as plasmacytoid dendritic cells (pDC)-like cells, that not only resembled pDCs but also shared conventional DC features.
[Science Immunology] |
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| The authors showed that glycolysis drove STING signaling to facilitate dendritic cell (DC)-mediated antitumor immune responses. Tumor-infiltrating DCs exhibited elevated glycolysis, and blockade of glycolysis by DC-specific Ldha/Ldhb double deletion resulted in defective antitumor immunity.
[Journal Of Clinical Investigation] |
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| Scientists showed by genomic profiling of a large cohort of metastatic pheochromocytomas/paragangliomas that high mutational load, microsatellite instability and somatic copy-number alteration burden were associated with ATRX/TERT alterations and were suitable prognostic markers.
[Nature Communications] |
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| Researchers detailed a multi-organ single-cell RNA sequencing of a mouse immune-mediated inflammatory diseases (IMIDs) model, and conducted meta-analyses of human IMIDs as well.
[Cell Reports Medicine] |
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| Investigators introduced a method that combined antibody-based cell barcoding with parallel droplet processing to automatically formulate cell population × stimulus combinations in a microfluidic device, and they applied it to profile the effects of 512 sequential stimulation conditions on human dendritic cells.
[Science Advances] |
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| Mapping of the oropharyngeal squamous cell carcinomas human leukocyte antigens (HLA) ligandome was performed by mass spectrometry based analysis of naturally presented HLA ligands isolated from tumor tissue samples (n = 40) using immunoaffinity purification.
[British Journal Of Cancer] |
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| Twelve participants with Idiopathic pulmonary fibrosis aged >50 years were blinded and randomized at a 1:1 ratio to either receive three weeks of dasatinib and quercetin, or matching placebo.
[Ebiomedicine] |
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| Scientists discuss intestinal B cells and their role when a loss of homeostasis results in intestinal and systemic inflammatory diseases.
[Nature Reviews Gastroenterology & Hepatology] |
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| The authors summarize the emerging role of tumor epithelial-to-mesenchymal plasticity in immune checkpoint blockade resistance and the tumor-intrinsic or extrinsic mechanisms by which tumors exploit this plasticity to achieve immunosuppression and immune escape.
[Cellular & Molecular Immunology] |
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| Investigators discuss the molecular biology underlying radiation-induced tumor immunity as well as pre-clinical and clinical studies combining radiation with immune checkpoint blockade treatments, with a focus on translational and clinical trials in small-cell lung cancer.
[Seminars In Cancer Biology] |
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| A Phase II proof-of-concept trial of farudodstat in alopecia areata is expected to start enrolling patients in the United States in the second quarter of 2023.
[ASLAN Pharmaceuticals] |
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| April 16 – 19, 2023
Snowbird, Utah, United States |
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| | University of Missouri – Columbia, Missouri, United States |
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| | Cornell University – Ithaca, New York, United States |
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| | University of Virginia – Charlottesville, Virginia, United States |
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| | National University of Singapore – Singapore, Singapore |
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| | The University of Melbourne – Melbourne, Australia |
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