Human Immunology News Volume 11.09 | Mar 7 2023

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    Laurisa Dohm
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    2023-03-07 | IIDN 11.09


    Human Immunology News by STEMCELL Technologies
    Vol. 11.09 – 7 March, 2023
    TOP STORY

    Etrasimod As Induction and Maintenance Therapy for Ulcerative Colitis (ELEVATE): Two Randomized, Double-Blind, Placebo-Controlled, Phase III Studies

    In two independent randomized, multicenter, double-blind, placebo-controlled phase III trials, adults with active moderate-to-severe ulcerative colitis and an inadequate or loss of response or intolerance to at least one approved ulcerative colitis therapy were assigned to once-daily oral etrasimod 2 mg, or placebo.
    [Lancet]

    Full Article
    PUBLICATIONSRanked by the impact factor of the journal

    Eosinophils Protect against Pulmonary Hypertension through 14-HDHA and 17-HDHA

    Eosinophil infiltration and chemotaxis were investigated in peripheral blood and lung tissues from pulmonary arterial hypertension patients without allergic history, and from sugen/hypoxia-induced pulmonary hypertension mice.
    [European Respiratory Journal]

    Full Article

    Long Non-Coding RNA-Derived Peptides Are Immunogenic and Drive a Potent Anti-Tumor Response

    When presented to the immune system as either ex vivo-loaded dendritic cells or expressed from a viral vector, lncRNA-derived peptides drove a potent antigen-specific CD8 T lymphocyte response, which translated into a significant delay in tumor growth.
    [Nature Communications]

    Full Article

    Safety and Immunogenicity of a Thermostable ID93 + GLA-SE Tuberculosis Vaccine Candidate in Healthy Adults

    Researchers presented results from a randomized, double-blinded Phase I clinical trial evaluating the safety, tolerability, and immunogenicity of a thermostable lyophilized single-vial presentation of the ID93 + GLA-SE vaccine candidate, compared to the non-thermostable two-vial vaccine.
    [Nature Communications]

    Full ArticlePress Release

    RELA Tunes Innate-Like Interferon I/III Responses in Human T Cells

    Scientists identified a transcriptional rheostat orchestrated by RELA that conferred human T cells with innate-like abilities to produce IFN-I/III. Despite intact cGAS-STING signaling, IFN-I/III responses were stunted in CD4+ T cells, compared with dendritic cells or macrophages.
    [Journal Of Experimental Medicine]

    Abstract

    PD-1 Blockade Plus Chemoradiotherapy As Preoperative Therapy for Patients with BRPC/LAPC: A Biomolecular Exploratory, Phase II Trial

    Investigators detailed findings from a phase II study of PD-1 blockade plus chemoradiotherapy as preoperative therapy for patients with locally advanced or borderline resectable pancreatic cancer. Twenty-nine patients were enrolled in the study.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Cytotoxic CD161−CD8+ TEMRA Cells Contribute to the Pathogenesis of Systemic Lupus Erythematosus

    Single-cell RNA sequencing of peripheral blood mononuclear cells from a systemic lupus erythematosus (SLE) family pedigree was performed to identify the SLE-associated CD8+ T cell subsets. Flow cytometry analysis of a SLE cohort, qPCR analysis of another SLE cohort, and public scRNA-seq datasets of autoimmune diseases were employed to validate the finding.
    [Ebiomedicine]

    Full Article

    Identification of Fibrocyte Cluster in Tumors Reveals the Role in Antitumor Immunity by PD-L1 Blockade

    Single-cell RNA sequencing of tumor-infiltrating CD45+ cells identified a distinct “fibrocyte cluster” from “macrophage clusters” in vivo, and in lung adenocarcinoma patients.
    [Cell Reports]

    Full ArticleGraphical Abstract

    The Early Neutrophil-Committed Progenitors Aberrantly Differentiate Into Immunoregulatory Monocytes during Emergency Myelopoiesis

    The human neutrophil-like monocytes were discriminated from CD14+CD16− classical monocytes by CXCR1 expression, and the capacity to suppress T cell proliferation.
    [Cell Reports]

    Full ArticleGraphical Abstract
    Explore the Science Events Calendar to discover conferences, podcasts, webinars, and more!
    REVIEWS

    Autophagy and Autophagy-Related Pathways in Cancer

    Scientists discuss and dissect the different functions of autophagy and autophagy-related processes during tumor development, maintenance, and progression.
    [Nature Reviews Molecular Cell Biology]

    Full Article

    From Gatekeepers to Providers: Regulation of Immune Functions by Cancer-Associated Fibroblasts

    The authors discuss the current understanding of cancer-associated fibroblasts (CAF)–immune interactions, their effect on tumor progression and therapeutic response, and the possibility of exploiting CAF–immune interactions as potential targets for cancer therapy.
    [Trends In Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    Compugen Doses First Patient in Triple Combination COM701, COM902, and Pembrolizumab MSS CRC Proof-of-Concept Study

    Compugen Ltd. announced that the first patient has been dosed in the triple combination proof-of-concept study evaluating COM701, in combination with COM902, and pembrolizumab in patients with metastatic microsatellite stable colorectal cancer (MSS CRC).
    [Compugen Ltd.]

    Press Release
    FEATURED EVENT

    EBMT 49th Annual Meeting

    April 23 – 26, 2023
    Paris, France

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    JOB OPPORTUNITIES

    Senior Scientist – Preclinical Immunotherapy of Cancer

    University Hospital Duesseldorf – Düsseldorf, Germany

    Postdoctoral Position – Vascular Biology & Tumor Immunology

    Uppsala University – Uppsala, Sweden

    Research Technician – RNA Vaccines and Therapies

    University of British Columbia – Vancouver, British Columbia, Canada

    Managing Director – Organoid Development Core Facility

    Rutgers Biomedical and Health Sciences – New Brunswick, New Jersey, United States

    Professor – Experimental Immunology

    Karolinska Institutet – Solna, Sweden

    > See All Jobs

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