 | | Vol. 11.10 – 14 March, 2023 |
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| The authors demonstrated that wide-spectrum antibiotics treatment prior to CD19-targeted CAR-T cell therapy was associated with adverse outcomes, but this effect was likely to be confounded by an increased pretreatment tumor burden and systemic inflammation in patients pretreated with such antibiotics.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators captured neoantigen-specific T cells from blood and tumors from patients with metastatic melanoma, with or without response to PD-1 immunotherapy, and then generated personalized libraries of neoantigen–HLA capture reagents to single-cell isolate the T cells and clone their T cell receptors.
[Nature] |
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| Researchers identified conserved behaviors of bone marrow-residing T cells in multiple myeloma patients undergoing BCMAxCD3 bispecific T cell engagers therapy.
[Cancer Cell] |
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| The authors showed that linoleic acid was a major positive regulator of CD8+ T cell activity by improving metabolic fitness, preventing exhaustion, and stimulating a memory-like phenotype with superior effector functions.
[Cell Metabolism] |
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| Tumor samples from patients with triple-negative breast cancer (TNBC) and non-TNBC revealed that increased numbers of CD56bright NK cells were present in TNBC tumors, and were correlated to poor overall survival in patients with TNBC.
[Science Translational Medicine] |
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| Scientists identified 16 patients from 10 families spanning three continents with a profound phenotype of early-life onset allergic immune dysregulation, including hypereosinophilia with esosinophilic gastrointestinal disease, asthma, elevated serum IgE, IgE-mediated food allergies, anaphylaxis, and other manifestations.
[Journal Of Experimental Medicine] |
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| Branched-chain amino acid (BCAA) supplementation recapitulated CD8+ T cell hyper-functions and synergized with anti-PD-1, in line with a better prognosis in non-small cell lung cancer patients containing high BCAAs when receiving anti-PD-1 therapy.
[Cell Reports] |
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| TRIB2 deficiency increased AKT activity and accelerated proliferation and differentiation in response to IL-7 in humans, and during lymphopenia in mice.
[Cell Reports] |
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| Scientists investigated the effects of the Bruton’s tyrosine kinase inhibitor, remibrutinib, on human blood basophils and CD34+-derived mast cells activation induced by serum obtained from chronic urticaria patients.
[Clinical And Translational Allergy] |
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| The authors discuss recent advances in our understanding of the tumor immune microenvironment and provide a comprehensive overview of the immune determinants of the pre-metastatic niches’ spatiotemporal evolution.
[Cancer Cell] |
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| Defence Therapeutics Inc. announced that it has signed a Collaboration Agreement with Orano Support SAS to develop the next generation of radio-immunoconjugates for radio-immunotherapy using Defence’s intracellular targeting technology.
[Defence Therapeutics (Yahoo! Finance)] |
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| The 2024 spending plan President Joe Biden unveiled continues his administration’s pattern of asking for large increases at major US research agencies.
[Science Insider] |
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| April 16 – 19, 2023
Snowbird, Utah, United States |
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| | Ume̴ University РUme̴, Sweden |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | University Hospital Duesseldorf – Düsseldorf, Germany |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | Karolinska Institutet – Solna, Sweden |
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