Human Immunology News Volume 11.12 | Mar 28 2023

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    Laurisa Dohm
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    2023-03-28 | HIN 11.12


    Human Immunology News by STEMCELL Technologies
    Vol. 11.12 – 28 March, 2023
    TOP STORY

    Neutralizing IL-8 Potentiates Immune Checkpoint Blockade Efficacy for Glioma

    Researchers examined the microenvironment in glioma and found that tumor-infiltrating T cells were mainly confined to the perivascular cuffs and expressed high levels of CCR5, CXCR3, and programmed cell death protein 1.
    [Cancer Cell]

    Full ArticleGraphical Abstract
    SepMateâ„¢ PBMC Isolation
    PUBLICATIONSRanked by the impact factor of the journal

    Cystic Fibrosis Reprograms Airway Epithelial IL-33 Release and Licenses IL-33 Dependent Inflammation

    Human airway epithelial cells grown from non-cystic fibrosis (CF) and CF cell lines and Cftr+/+ and Cftr-/- mice were used to test whether CF transmembrane conductance regulator-deficiency increased IL-33 expression/release, and if deletion of IL-33 reduced allergen-induced inflammation in the CF lung.
    [American Journal Of Respiratory And Critical Care Medicine]

    Abstract

    Single Cell Analysis in Head and Neck Cancer Reveals Potential Immune Evasion Mechanisms during Early Metastasis

    ScRNAseq analyses of tumor-infiltrating CD8 + T lymphocytes showed two distinct trajectories to T cell dysfunction, corroborated by their clonal architecture based on single-cell T cell receptor sequencing.
    [Nature Communications]

    Full Article

    Stromal and Therapy-Induced Macrophage Proliferation Promotes PDAC Progression and Susceptibility to Innate Immunotherapy

    Scientists showed that in pancreatic ductal adenocarcinomas (PDAC), proliferation of tumor-associated macrophagess could be driven by colony stimulating factor-1 produced by cancer-associated fibroblasts.
    [Journal Of Experimental Medicine]

    Abstract

    Single-Cell Profiling Identifies a Novel Human Polyclonal Unconventional T Cell Lineage

    Single-cell RNA sequencing confirmed a common developmental trajectory between the thymic and blood unconventional T cells and clearly delineated this unconventional lineage in blood.
    [Journal Of Experimental Medicine]

    Full Article

    Identification of Shared Characteristics in Tumor-Infiltrating T Cells across 15 Cancers

    Scientists conducted a pan-cancer analysis of 349,799 T cells across 15 cancers, showing that the same T cell types had similar expression patterns regulated by specific transcription factor regulons across cancers.
    [Molecular Therapy – Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    Cholesterol Suppresses Human iTreg Differentiation and nTreg Function through Mitochondria-Related Mechanisms

    Mechanistically, cholesterol induced the production of mitochondrial reactive oxygen species in naïve T cells, inhibiting the degradation of HIF-1α and unleashing its inhibitory effects on induced Treg (iTreg) differentiation.
    [Journal Of Translational Medicine]

    Full Article

    Generation of Functional Thymic Organoids from Human Pluripotent Stem Cells

    Researchers showed the generation of thymic epithelial cells in vitro in isogenic stem cell-derived thymic organoids, consisting of thymic epithelial progenitors, hematopoietic progenitor cells, and mesenchymal cells, differentiated from the same human pluripotent stem cell line.
    [Stem Cell Reports]

    Full Article

    Efficacy of Coxsackievirus A21 against Drug-Resistant Neoplastic B Cells

    Investigators demonstrated that the oncolytic virus, Coxsackievirus A21, could kill a range of B cell neoplasms, irrespective of an anti-viral interferon response.
    [Molecular Therapy Oncolytics]

    AbstractFull ArticleGraphical Abstract
    Stay current with COVID-19 research. Read Immunology of Infectious Disease News now.
    REVIEWS

    Splenic Stromal Niches in Homeostasis and Immunity

    The authors examine the current understanding of how stromal niches and neuroimmune circuits direct the immunological functions of the spleen, with a focus on T cell immunity.
    [Nature Reviews Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Cullinan Oncology Announces US FDA Clearance of Investigational New Drug Application for CLN-617, a Novel Fusion Protein Harnessing Il-2 and Il-12 Cytokines

    Cullinan Oncology, Inc. announced the US FDA has cleared its Investigational New Drug application for CLN-617, a fusion protein comprised of two potent and synergistic antitumor cytokines, IL-2 and IL-12, with a collagen binding domain designed for retention in the tumor microenvironment.
    [Cullinan Oncology, Inc]

    Press Release
    FEATURED EVENT

    Inflammation in the Lung: Friend or Foe in Viral Infections?

    April 23 – 26, 2023
    Snowbird, Utah, United States

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    JOB OPPORTUNITIES

    Centre Head – Innate Immunity and Infectious Diseases

    Hudson Institute of Medical Research – Melbourne, Australia

    Assistant Professor – Immunology

    Dana-Farber Cancer Institute and Harvard Medical School – Boston, Massachusetts, United States

    Postdoctoral Fellowship – Cancer Research and Tumor Immunology

    Ume̴ University РUme̴, Sweden

    Postdoctoral Research Fellow – Tumor-on-Chip Metastasis Model

    Oslo University Hospital – Oslo, Norway

    Senior Scientist – Preclinical Immunotherapy of Cancer

    University Hospital Duesseldorf – Düsseldorf, Germany

    > See All Jobs

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