 | | Vol. 11.13 – 4 April, 2023 |
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| Researchers demonstrated that a virus-immune axis controlled the senescent fibroblast accumulation in the human skin. Senescent fibroblasts increased in old skin compared with young skin.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors found patients with short telomere syndromes were only predisposed to squamous cell carcinoma of the head and neck, anus, or skin, a spectrum reminiscent of cancers seen in patients with immunodeficiency.
[Cancer Cell] |
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| Researchers report 23 patients with loss of function variants which caused autosomal recessive, complete STAT2 deficiency. Both cells transfected with mutant STAT2 alleles and the patients’ cells displayed impaired expression of interferon stimulated genes, and impaired control of in vitro viral infections.
[Journal Of Clinical Investigation] |
| | Investigators applied single-cell transcriptomics to characterize the monocytes that were significantly enriched in the peripheral blood mononuclear cells of high-altitude pulmonary hypertension patients.
[Nature Communications] |
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| Xenogeneic cross-circulation supported the viability, tissue integrity, and physiologic improvement of human donor lungs over 24 hours of xeno-support.
[Science Advances] |
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| By mass spectrometry, 1644 differentially expressed proteins, especially delta-like 4 (Dll4), were detected in the urine exosomes of diabetic nephropathy patients compared with controls, which was confirmed by western blot assay.
[Molecular Therapy] |
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| The authors found that human T cell choline acetyltransferase (ChAT) mRNA expression was induced by T cell activation involving the phosphoinositide 3-kinase signaling cascade.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists derived the transcriptional and epigenetic programs of resting and ex vivo activated, circulating CD4+ and CD8+ human memory T cells subsets.
[Communications Biology] |
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| Researchers demonstrated the robustness of an Assay for Transposase Accessible Chromatin Sequencing (ATAC-seq) protocol comparing primary Treg cells recovered from fresh or cryopreserved peripheral blood mononuclear cell samples, in the steady state and in response to stimulation.
[Scientific Reports] |
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| The authors discuss how vaccination strategies aimed at generating a broad and robust T cell response may offer superior protection against pathogens, particularly those that have been observed to mutate rapidly.
[Nature Reviews Immunology] |
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| Scientists review the application of liquid biopsy in predicting the outcomes of immunotherapy in non-small cell lung cancer patients, and discuss the challenges and future directions in this field.
[Cell Death & Disease] |
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| The collaboration will bring together Regeneron’s VelociSuite® technologies for the discovery and characterization of fully human antibodies and T cell receptors, with Sonoma Biotherapeutics’ approach to developing and manufacturing gene-modified Treg cell therapies.
[Regeron Inc.] |
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| April 23 – 28, 2023
Cancun, Mexico |
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| | University of Southern California – Los Angeles, California, United States |
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| | Institute of Cancer Research – London, England, United Kingdom |
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| | Pfizer, Inc.- Cambridge, Massachusetts, United States |
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| | Hudson Institute of Medical Research – Melbourne, Australia |
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| | Dana-Farber Cancer Institute and Harvard Medical School – Boston, Massachusetts, United States |
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