 | | Vol. 11.14 – 11 April, 2023 |
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| The authors studied how genome configuration was integrated with CD8+ T cell differentiation during infection, and investigated the role of CTCF, a key chromatin remodeler, in modulating CD8+ T cell fates through CTCF knockdown approaches and perturbation of specific CTCF-binding sites.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that tolerance in skin was controlled by microbial interaction with a specialized subset of antigen-presenting cells. CD301b+ type 2 conventional dendritic cells in neonatal skin were specifically capable of uptake and presentation of commensal antigens for the generation of regulatory T cells.
[Immunity] |
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| Investigators analyzed seven molecular datasets of samples from patients with advanced melanoma treated with immune checkpoint inhibitor agents to investigate clinical, genomic, and transcriptomic features of anti-PD-1 response in cutaneous melanoma.
[Cancer Cell] |
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| Analysis of human and murine hepatic and pulmonary fibrosis samples revealed accumulation of CD9+TREM2+ macrophages near scar sites and proximal to activated mesenchymal cells.
[Science Immunology] |
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| Investigators showed that circulating tumor-reactive lymphocytes could be isolated from peripheral blood at high yield and purity via microfluidic immunomagnetic cell sorting, allowing for comprehensive downstream analyses of these rare cells.
[Nature Biomedical Engineering] |
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| Scientists observed higher CD8+ T cell infiltration, immune checkpoint expression, and exhausted T cells after treatment.
[Nature Cancer] |
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| In patients who experienced partial response or stable disease, elevated Igα2 expression correlated with T- and B-cell infiltration, suggesting that tertiary lymphoid structures existed in these patients’ tumors.
[Nature Cancer] |
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| The authors reported broad expression of six transmembrane epithelial antigen of the prostate 1 (STEAP1) relative to prostate-specific membrane antigen in lethal metastatic prostate cancers and the development of a STEAP1-directed CAR T cell therapy.
[Nature Communications] |
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| Researchers studied the cell-intrinsic response of lung cancer to interferon-γ (IFNγ), a cytokine that promotes immunoresponse and modulates PD-L1 levels.
[Cell Reports Medicine] |
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| Scientists summarize the basic principles of oncolytic viruses (OVs) in terms of their classifications, as well as the recent advances in OV-modification strategies based on their characteristics, biofunctions, and cancer hallmarks.
[Signal Transduction And Targeted Therapy] |
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| Researchers discuss the latest advances in the field of miRNA-encapsulating nanoparticles in cancer, focusing on colorectal cancer and its metastatic forms, one of the most common malignancies worldwide.
[Molecular Therapy-Nucleic acids] |
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Immutep Limited announced it has signed an agreement to expand the INSIGHT-003 trial evaluating the combination of eftilagimod alpha in conjunction with standard-of-care combination of anti-PD-1 therapy and chemotherapy in first line non- small cell lung cancer.
[Immuntep Limited] |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Cincinnati Children’s Hospital – Cincinnati, Ohio, United States |
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| | The Beckman Research Institute of City of Hope – Duarte, California, United States |
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| | University of Oklahoma – Oklahoma City, Oklahoma, United States |
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| | Institute of Cancer Research – London, England, United Kingdom |
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