Human Immunology News Volume 11.15 | Apr 18 2023

    By
    Laurisa Dohm
    -
    0
    29








    2023-04-18 | HIN 11.15


    Human Immunology News by STEMCELL Technologies
    Vol. 11.15 – 18 April, 2023
    TOP STORY

    Phenotypic Plasticity and Reduced Tissue Retention of Exhausted Tumor-Infiltrating T Cells following Neoadjuvant Immunotherapy in Head and Neck Cancer

    TGF-β-driven CD103 expression on CD8+ T cells was reversed following TGF-β neutralization in vitro, implicating TGF-β in T cell tissue retention and impaired systemic immunity.
    [Cancer Cell]

    AbstractGraphical Abstract
    Cell Preparation For Crossmatch Assays
    PUBLICATIONSRanked by the impact factor of the journal

    A Lentiviral Vector for the Production of T Cells with an Inducible Transgene and a Constitutively Expressed Tumor-Targeting Receptor

    The vector allowed for the delivery of a variety of genes to human T cells, as shown for interleukin-2 and a microRNA-based short hairpin RNA for the knockdown of the gene coding for haematopoietic progenitor kinase 1, a negative regulator of T-cell-receptor signaling.
    [Nature Biomedical Engineering]

    Full Article

    Multiomics and Spatial Mapping Characterizes Human CD8+ T Cell States in Cancer

    Using multiomics analysis of CD8+ T cell features across multiple patient cohorts and tumor types, investigators identified tumor niche–dependent exhausted and other types of hypofunctional CD8+ T cell states.
    [Science Translational Medicine]

    Abstract

    Hypoimmune Anti-CD19 Chimeric Antigen Receptor T Cells Provide Lasting Tumor Control in Fully Immunocompetent Allogeneic Humanized Mice

    Scientists generated human hypoimmune T cells with disrupted B2M, CIITA, and TRAC genes using CRISPR-Cas9 editing. In addition, CD47 and anti-CD19 CAR were expressed using lentiviral transduction.
    [Nature Communications]

    Full Article

    Deficiency of the CD155-CD96 Immune Checkpoint Controls IL-9 Production in Giant Cell Arteritis

    Researchers reported that patients with the autoimmune vasculitis giant cell arteritis (GCA) had a defective CD155-CD96 immune checkpoint. Macrophages from patients with GCA retained the checkpoint ligand CD155 in the endoplasmic reticulum, and failed to bring it to the cell surface.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    A Novel Patient-Derived 3D Model Recapitulates Mantle Cell Lymphoma Lymph Node Signaling, Immune Profile and In Vivo Ibrutinib Responses

    To capture disease heterogeneity and tumor microenvironment cues, the authors developed the first patient-derived Mantle cell lymphoma spheroids that recapitulated tumor oncogenic pathways and immune microenvironment in a multiplexed system that allowed easy drug screening, including immunotherapies.
    [Leukemia]

    Full Article

    A Mutagenesis Study of Autoantigen Optimization for Potential T1D Vaccine Design

    Scientists probed HLA-X-idiotype-T cell receptors (TCR) binding and designed enhanced-reactive pHLA-TCR antigens using an in silico mutagenesis approach which they functionally validated by cell proliferation assays and flow cytometry.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    AKT Activity Orchestrates Marginal Zone B Cell Development in Mice and Humans

    In humans, splenic immunoglobulin (Ig) D+CD27+ B cells displayed higher AKT signaling than naive IgD+CD27− and memory IgD−CD27+ B cells, and developed in an AKT-dependent manner from their precursors in vitro.
    [Cell Reports]

    Full ArticleGraphical Abstract

    CISH Impairs Lysosomal Function in Activated T Cells Resulting in Mitochondrial DNA Release and Inflammaging

    Investigators showed that activated T cells from older adults contributed to inflammaging by releasing mitochondrial DNA into their environment due to an increased expression of the cytokine-inducible SH2-containing protein (CISH).
    [Nature Aging]

    Abstract
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    REVIEWS

    Immune Checkpoint Therapy—Current Perspectives and Future Directions

    Scientists highlight the biology of anti-tumor immunity underlying response and resistance to immune checkpoint therapy (ICT), discuss efforts to address the current challenges with ICT, and outline strategies to guide the development of subsequent clinical trials and combinatorial efforts with ICT.
    [Cell]

    Full Article

    Metabolism in Type 2 Immune Responses

    The authors discuss recent progress in understanding how metabolic regulation relates to type 2 immunity firstly by considering specifics of metabolism within type 2 immune cells, and secondly by stressing how type 2 immune cells are integrated more broadly into the metabolism of the organism as a whole.
    [Immunity]

    Full Article
    INDUSTRY AND POLICY NEWS

    SAB Biotherapeutics Announces US FDA Grants Breakthrough Therapy Designation to SAB-176 Influenza Immunotherapy

    SAB Biotherapeutics announced that the US FDA has granted Breakthrough Therapy Designation to SAB-176, an investigational therapeutic, for post-exposure prophylaxis for Type A and Type B influenza illness in high-risk patients, including those who have anti-viral resistant strains.
    [SAB Biotherapeutics]

    Press Release
    FEATURED EVENT

    Neuroimmune Interactions: From Basic Mechanisms to Novel Therapeutic Directions

    May 15 – 19, 2023
    Whistler, British Columbia, Canada

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Single-Cell Multiomics in T Cell Biology

    Karolinska Institutet – Solna, Sweden

    Senior Research Technician – Genetic Medicine

    The University of Chicago – Chicago, Illinois, United States

    Specialist – Cell Processing

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Fellow – Herpesvirus Vaccine Development

    The Beckman Research Institute of City of Hope – Duarte, California, United States

    Postdoctoral Scholar – Immunotherapy for Glioblastoma

    University of Southern California – Los Angeles, California, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Human Immunology News Twitter