 | | Vol. 11.16 – 25 April, 2023 |
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| Researchers assessed cross-reactive and virus-specific CD4+ and CD8+ T cells in healthy individuals and mpox convalescent donors. Cross-reactive T cells were most frequently observed in healthy donors over 45 years.
[Cell Host & Microbe] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that the yields of edited primary human lymphocytes could be increased substantially by delivering a CRISPR ribonucleoprotein mixed with an amphiphilic peptide identified through screening.
[Nature Biomedical Engineering] |
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| The authors used stable isotope labelling with deuterated water to quantify memory CD8+ T cell survival in healthy individuals and patients with chronic viral infections.
[Journal Of Clinical Investigation] |
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| Investigators characterized the spatial cellular distribution of immune cell populations using 23 makers placed in five multiplex immunofluorescence panels and their associations with clinicopathologic variables and outcomes.
[Nature Communications] |
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| The authors engineered a monoclonal immunoglobin (Ig) E antibody with human constant domains recognizing CSPG4 to target melanoma. CSPG4 IgE bound to human melanomas including metastases, mediated tumoricidal antibody-dependent cellular cytotoxicity, and stimulated human IgE Fc-receptor-expressing monocytes towards pro-inflammatory phenotypes.
[Nature Communications] |
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| Investigators reported that Bestrophin1 (BEST1), a component protein of Ca2+-activated Cl− channels, was highly expressed on classical monocytes in the peripheral blood of head and neck squamous cell carcinomas patients.
[Advanced Science] |
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| Scientists showed that AML-derived macrophages present immunosuppressive and pro-leukemogenic functions, in part related to the acquisition of AML mutations.
[Science Advances] |
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| The authors reported on a Phase I/II non-randomized trial of escalating doses of ex-vivo expanded HER2 specific T-cells after in vivo priming with a multiple peptide-based HER2 intracellular domain vaccine.
[Clinical Cancer Research] |
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| Using quantitative mass spectrometry, scientists identified the activation of two MYC-controlled metabolic pathways, amino acid transport and glycolysis, both of which were necessary for mucosal-associated invariant T cell proliferation.
[Science Signaling] |
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| The authors present the strengths and weaknesses of patient-derived xenograft models and highlight the integration of novel technologies in patient-derived xenograft model research.
[Signal Transduction And Targeted Therapy] |
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| Scientists discuss insights into the tumor-modulating roles of autophagy in different contexts and reflect on how future studies using physiological culture systems may help to understand the complexity and open new therapeutic avenues.
[Nature Cancer] |
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| The patent covers treatment with an immunotherapy that targets a neoantigen predicted to be presented by a human leukocyte antigen (HLA) allele that has not been lost in a tumor, where loss of HLA alleles is determined using a proprietary sequence-based method.
[Achilles Therapeutics plc] |
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| May 28 – 31, 2023
Vancouver, British Columbia, Canada |
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| | University Medical Center Groningen – Groningen, Netherlands |
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| | Karolinska Institutet – Solna, Sweden |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Hudson Institute of Medical Research – Melbourne, Australia |
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| | Rutgers New Jersey Medical School – Newark, New Jersey, United States |
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