Human Immunology News Volume 11.17 | May 2 2023

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    Laurisa Dohm
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    2023-05-02 | HIN 11.17


    Human Immunology News by STEMCELL Technologies
    Vol. 11.17 – 2 May, 2023
    TOP STORY

    Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators

    Pooled CRISPR-Cas9 screening in vivo, using a chimeric hematopoietic stem cell transplant model, confirmed the essentiality of eight master regulators in tumor-infiltrating regulatory T cells recruitment and/or retention without affecting other T cell subtypes.
    [Cancer Cell]

    AbstractGraphical Abstract
    Quantify Cytokines with Confidence with High-Performance ELISA Kits
    PUBLICATIONSRanked by the impact factor of the journal

    Alternative Splicing of GSDMB Modulates Killer Lymphocyte–Triggered Pyroptosis

    Upon NK cell attack, gasdermin B (GSDMB)3-expressing cells died by pyroptosis, whereas GSDMB4-expressing cells died by mixed pyroptosis and apoptosis, and GSDMB1/2-expressing cells died only by apoptosis.
    [Science Immunology]

    Abstract

    PPAR-γ Regulates the Effector Function of Human T Helper 9 Cells by Promoting Glycolysis

    In vitro and ex vivo experiments showed that the PPAR-γ-mTORC1-interluekin-9 pathway was active in TH9 cells in human skin inflammation.
    [Nature Communications]

    Full Article

    Human iPSC-Derived Proinflammatory Macrophages Cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System

    Human induced pluripotent stem cell derived macrophages (iMACs) and adipocytes (iADIPOs) were cocultured in a microphysiological system. iMACs migrated toward and infiltrated into the 3D iADIPOs cluster to form crown-like structures-like morphology around damaged iADIPOs.
    [Small]

    Full Article

    Uncoupling CD4+ TIL-Mediated Tumor Killing from JAK-Signaling in Melanoma

    To determine the role of cytotoxic CD4+ tumor-infiltrating lymphocytes (TILs) in immune checkpoint blockade-resistant tumors, scientists investigated CD4+ TIL-mediated cytotoxicity in matched pairs of TILs and autologous melanoma cell lines, used as a model of patient-specific immune-tumor interaction.
    [Clinical Cancer Research]

    Abstract

    IL12/18/21 Pre-Activation Enhances the Anti-Tumor Efficacy of Expanded γδT Cells and Overcomes Resistance to Anti-PD-L1 Treatment

    The authors reported that cytokine pre-treatment with interluekin (IL)12/18, IL12/15/18, IL12/18/21, and IL12/15/18/21 effectively enhanced the activation and cytotoxicity of in vitro-expanded murine and human γδT cells.
    [Cancer Immunology Research]

    Abstract

    PSGL-1 Attenuates Early TCR Signaling to Suppress CD8+ T Cell Progenitor Differentiation and Elicit Terminal CD8+ T Cell Exhaustion

    PSGL-1 deficiency empowered CD8+ T cells to respond to low-affinity T cell receptor ligands and inhibited growth of PD-1-blockade-resistant melanoma by enabling tumor-infiltrating T cells to sustain an elevated metabolic gene signature.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Defective Peripheral B Cell Selection in Common Variable Immune Deficiency Patients with Autoimmune Manifestations

    Researchers found that receptor editing, a measure of central tolerance, was increased in transitional B cells from common variable immune deficiency (CVID) patients, and that these cells had a higher immunoglobulin κ:λ ratio in CVID patients with autoimmune manifestations than in those with infection only.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Allogenic and Autologous Anti-CD7 CAR-T Cell Therapies in Relapsed or Refractory T Cell Malignancies

    Scientists launched a Phase I trial to explore differences between autologous and allogeneic anti-CD7 CAR-T therapies in T cell acute lymphoblastic leukemia and lymphoma.
    [Blood Cancer Journal]

    Full Article
    Explore Antibodies for Immunology Research
    REVIEWS

    Insights from a 30-Year Journey: Function, Regulation, and Therapeutic Modulation of PD1

    The authors outline the journey from the discovery of PD1 to its role as a breakthrough target in cancer immunotherapy, describing its regulation and function, and examining how a mechanistic understanding of PD1 signaling suggests a central function in setting the T cell activation threshold.
    [Nature Reviews Immunology]

    Abstract

    Immune Mechanisms of Toxicity from Checkpoint Inhibitors

    Scientists discuss the current understanding of the inflammatory toxicities from immune checkpoint inhibitors, and propose optimal treatment strategies for these toxicities.
    [Trends In Cancer]

    Full Article
    INDUSTRY AND POLICY NEWS

    AbbVie Closes Cystic Fibrosis Chapter after Combo ‘Just Did Not Work’

    AbbVie is discontinuing all work in cystic fibrosis after a Phase II flop, while also scrapping another Phase II program in immunology.
    [Fierce Biotech]

    News Article

    Arbutus Announces FDA Clinical Hold on IND Application for AB-101, an Oral PD-L1 Inhibitor

    Arbutus Biopharma Corporation announced that they were notified via verbal communication from the US FDA that the AB-101 Investigational New Drug (IND) application has been placed on clinical hold.
    [Arbutus Biopharma Corp.]

    Press Release
    FEATURED EVENT

    The 2023 ASCO Annual Meeting

    June 2 – 6, 2023
    Chicago, Illinois, United States

    > See All Events

    JOB OPPORTUNITIES

    Research/Senior Scientist – Oncology Drug Discovery Biotherapeutics

    Novartis – Cambridge, Massachusetts, United States

    Senior Laboratory Technician – Angiogenesis & Vascular Metabolism

    VIB-KU Leuven Center for Cancer Biology – Leuven, Belgium

    Postdoctoral Fellow – Cancer Biology

    Wake Forest University – Winston Salem, North Carolina, United States

    Postdoctoral Research Fellow – Infection and Immunity

    The University of Southern California – Los Angeles, California, United States

    Postdoctoral Position – Single-Cell Multiomics in T Cell Biology

    Karolinska Institutet – Solna, Sweden

    > See All Jobs

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