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| Scientists showed that central nervous system-resident astrocytes and infiltrating CD44hiCD4+ T cells generated interleukin-3, while microglia and recruited myeloid cells expressed interleukin-3 receptor-ɑ.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors found that resting TH9 cells produced IL-9 independently of T cell receptor restimulation, due to STAT5- and STAT6-dependent bystander activation. This mechanism was seen in circulating cells from allergic patients and was restricted to recently activated cells.
[Nature Immunology] |
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| IL9-expressing pathogenic T2 cells were specific to asthmatic airways and were only observed after allergen challenge. Additionally, conventional type 2 dendritic cells and CCR2-expressing monocyte-derived cells were uniquely enriched in asthmatics after allergen.
[Science Immunology] |
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| Scientists surveyed 61 tumor regions and adjacent nonmalignant lung tissues from eight patients with lung cancer and performed deep antigen discovery combining immunopeptidomics, genomics, bulk and spatial transcriptomics, and explored the heterogeneous expression and presentation of tumor (neo)antigens.
[Nature Cancer] |
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| Investigators developed nutrient-deprived media and a conditional knockout female mouse model to study the mechanism underlying PD-1 upregulation. Reduced methionine increased PD-1 expression on CD4 T cells.
[Nature Communications] |
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| Scientists sharacterized circRNA expression profiles in two independent cohorts of 157 immune checkpoint blockade (ICB)-treated advanced melanoma patients and revealed overall overexpression of circRNAs in ICB non-responders in both pre-treatment and early during therapy.
[Nature Communications] |
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| Researchers reported a dysregulated colonic innate lymphoid cells (ILC) composition in pediatric inflammatory bowel disease colitis that correlated with inflammatory activity, including accumulation of naive-like CD45RA+CD62L− ILCs.
[Cell Reports Medicine] |
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| The authors investigated the heterogeneity of trained immunity induction by single-cell RNA sequencing of immune cells collected from 156 samples.
[Cell Reports] |
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| Investigators observed that addition of healthy donor-derived purified NK cells to BM samples from patients with either primary or acquired daratumumab-resistance improved daratumumab-mediated multiple myeloma cell killing.
[Hemasphere] |
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| Scientists summarize the current understanding of autoimmune disease genetics, including shared effects, mechanisms, and evolutionary origins.
[Science] |
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| The authors describe the distinct physical features of the peritumoral microenvironment and link their relationship to immune responses.
[Trends In Cancer] |
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| INmune Bio, Inc. announced today the US FDA has cleared the Investigational New Drug (IND) application for INKmune™, a novel natural killer cell immunotherapy, for a Phase I/II open-label clinical trial for the treatment of metastatic castration-resistant prostate cancer.
[INmune Bio, Inc.] |
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| June 6 – 10, 2023
Keystone, Colorado, United States |
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| | Calico Life Sciences LLC – San Francisco, California, United States |
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| | California Institute of Technology – Pasadena, California, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Karolinska Institutet – Solna, Sweden |
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