Human Immunology News Volume 11.19 | May 16 2023

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    Laurisa Dohm
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    2023-05-16 | HIN 11.19


    Human Immunology News by STEMCELL Technologies
    Vol. 11.19 – 16 May, 2023
    TOP STORY

    Anti-GD2 CAR-NKT Cells in Relapsed or Refractory Neuroblastoma: Updated Phase I Trial Interim Results

    Investigators reported updated interim results from the first-in-human phase I evaluation of autologous natural killer T cells (NKTs) co-expressing a GD2-specific chimeric antigen receptors (CAR) with interleukin 15 in 12 children with neuroblastoma.
    [Nature Medicine]

    AbstractPress Release
    Use ImmunoCultâ„¢ to differentiate mouse CD4+ cells to Tregs.
    PUBLICATIONSRanked by the impact factor of the journal

    Personalized RNA Neoantigen Vaccines Stimulate T Cells in Pancreatic Cancer

    In a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex nanoparticles, the authors synthesized mRNA neoantigen vaccines in real time from surgically resected pancreatic ductal adenocarcinoma tumors.
    [Nature]

    Full ArticlePress Release

    Remodeling of the Immune and Stromal Cell Compartment by PD-1 Blockade in Mismatch Repair-Deficient Colorectal Cancer

    Researchers utilized single-cell RNA sequencing to investigate the dynamics of immune and stromal cells in 19 patients with mismatch repair-deficient and microsatellite instability-high colorectal cancers who received neoadjuvant PD-1 blockade.
    [Cancer Cell]

    AbstractGraphical Abstract

    CTLA4 Protects against Maladaptive Cytotoxicity during the Differentiation of Effector and Follicular CD4+ T Cells

    Investigators performed single-cell RNA-seq analysis of matched CD57+ CD4+ T cells from blood and tonsil samples.
    [Cellular & Molecular Immunology]

    Full Article

    Preclinical Characterization of the Toll-Like Receptor 7/8 Antagonist MHV370 for Lupus Therapy

    In vitro, MHV370 inhibited Toll-like receptors 7/8-dependent production of cytokines in human and mouse cells, notably interferon-α, a clinically validated driver of autoimmune diseases.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Intratumoral Erythroblastic Islands Restrain Anti-Tumor Immunity in Hepatoblastoma

    By single-cell RNA sequencing of 13 treatment-naive hepatoblastoma patients, scientists discovered an immune landscape characterized by aberrant accumulation of erythroblastic islands, formed by VCAM1+ macrophages and erythroid cells.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Oxidative Stress Enhances the Therapeutic Action of a Respiratory Inhibitor in MYC-Driven Lymphoma

    In a B-lymphoid cell line, ectopic MYC activity and treatment with IACS-010759 added up to induce oxidative stress, with consequent depletion of reduced glutathione and lethal disruption of redox homeostasis.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Chimeric TIM-4 Receptor-Modified T Cells Targeting Phosphatidylserine Mediates Both Cytotoxic Anti-Tumor Responses and Phagocytic Uptake of Tumor-Associated Antigen for T Cell Cross Presentation

    Researchers engineered a chimeric engulfment receptor, CER-1236, that combined the extracellular domain of TIM-4 with intracellular signaling domains, TLR2/TIR, CD28, and CD3ζ, to enhance both TIM-4-mediated phagocytosis and T cell cytotoxic function.
    [Molecular Therapy]

    AbstractFull ArticleGraphical Abstract

    Single Cell Profiling at the Maternal–Fetal Interface Reveals a Deficiency of PD-L1+ Non-Immune Cells in Human Spontaneous Preterm Labor

    Among the immune cells, maternal PD1+ CD8 T cell subsets were less abundant in term laboring compared to term non-laboring women.
    [Scientific Reports]

    Full Article
    Cell Preparation For Crossmatch Assays
    REVIEWS

    Protein Kinases: Drug Targets for Immunological Disorders

    The authors provide an overview of the status of small molecule inhibitors specifically generated to target protein kinases relevant to immune cell function, with an emphasis on those approved for the treatment of immune-mediated diseases.
    [Nature Reviews Immunology]

    Full Article

    T Helper 2 Cells in Asthma

    Scientists provide an update of the current understanding of T helper 2 cells in human asthma, highlighting their many guises and functions in asthma, both pathogenic and regulatory, and how these are influenced by the tissue location and disease stage and severity.
    [Journal Of Experimental Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Historic $100 Million Gift to Brigham and Women’s Hospital to Establish Institute of Immunology and Inflammation of the Brigham, Massachusetts Gener

    Brigham and Women’s Hospital announced a historic $100 million gift from eminent biotechnology entrepreneur Gene Lay, MS, DVM, founder and CEO of BioLegend, Inc., through the Laygend Foundation.
    [Brigham and Women’s Hospital]

    Press Release
    FEATURED EVENT

    B Cell Biology in the Context of Infectious Diseases, Autoimmunity and B Cell Cancers

    June 6 – 10, 2023
    Keystone, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Scientist – Immunotherapy

    Max Delbrück Center for Molecular Medicine – Berlin, Germany

    Postdoctoral Fellow – Tumor Microenvironment

    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    Postdoctoral Positions – Reproductive Immunology and Pregnancy Biology

    University of California San Francisco – San Francisco, California, United States

    Principal Investigator – Immune System Aging and Inflammation

    Calico Life Sciences LLC – San Francisco, California, United States

    Postdoctoral Positions – Cancer 3D Genome

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    > See All Jobs

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