Human Immunology News Volume 11.20 | May 23 2023

    By
    Bob
    -
    0
    19








    2023-05-23 | HIN 11.20


    Human Immunology News by STEMCELL Technologies
    Vol. 11.20 – 23 May, 2023
    TOP STORY

    Phenotypic Diversity of T Cells in Human Primary and Metastatic Brain Tumors Revealed by Multiomic Interrogation

    To interrogate the potential roles of T cells in this process, the authors profiled these cells from individuals with primary or metastatic brain cancers via integrated analyses on the single-cell and bulk population levels.
    [Nature Cancer]

    Full Article
    Explore Antibodies for Immunology Research
    PUBLICATIONSRanked by the impact factor of the journal

    Obesity Alters Monocyte Developmental Trajectories to Enhance Metastasis

    Investigators showed that obesity-induced monocytes underlie neutrophil activation and breast cancer lung metastasis.
    [Journal Of Experimental Medicine]

    Abstract

    Immune Microenvironment Remodeling after Radiation of a Progressing Brain Metastasis

    Researchers presented a detailed immunological analysis of two tumors from a patient with multiple non-small cell lung cancer metastases to the brain.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Tumor-Derived Semaphorin 4A Improves PD-1–Blocking Antibody Efficacy by Enhancing CD8+ T Cell Cytotoxicity and Proliferation

    Scientists demonstrated that histologically semaphorin 4A (Sema4A)-positive non–small cell lung cancer (NSCLC) responded significantly better to anti–programmed cell death 1 (PD-1) antibody than Sema4A-negative NSCLC.
    [Science Advances]

    Full Article

    HLA Class II Loss and JAK1/2 Deficiency Coevolve in Melanoma Leading to CD4 T Cell and IFNγ Cross-Resistance

    Researchers investigated evolution of HLA class II-loss tumors that escaped cytotoxic CD4 T cell activity and contributed to immunotherapy resistance.
    [Clinical Cancer Research]

    Abstract

    Actuation of Single Downstream Nodes in Growth Factor Network Steers Immune Cell Migration

    By optogenetically targeting different nodes in the Ras/PI3K/Akt network in differentiated human HL-60 neutrophils, scientists abruptly altered protrusive activity, bypassing the chemoattractant receptor/G-protein network.
    [Developmental Cell]

    AbstractGraphical Abstract

    An Isoform of the Giant Protein Titin Is a Master Regulator of Human T Lymphocyte Trafficking

    Investigators described the unexpected role of titin, the largest protein encoded by the human genome, in the regulation of mechanisms of lymphocyte trafficking.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Inhibiting N-glycan Processing Increases the Antibody Binding Affinity and Effector Function of Human Natural Killer Cells

    The authors evaluated the impact of treatment with kifunensine, an inhibitor of asparagine-linked (N-)glycan processing, on antibody-dependent cell-mediated cytotoxicity using primary and cultured human NK cells.
    [Immunology]

    Full Article

    Cancer Cells Promote Immune Regulatory Function of Macrophages by Upregulating Scavenger Receptor MARCO Expression

    Scientists reported that cancer cells could upregulate surface macrophage receptors with collagenous structure (MARCO) expression on human macrophages not only via IL-6–induced STAT3 activation but also via sphingosine-1-phosphate receptor-mediated IL-6 and IL-10 expression followed by STAT3 activation.
    [Journal of Immunology]

    Abstract
    How to prioritize and manage your research projects
    REVIEWS

    Epigenetic Regulation in the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Targets

    Investigators present an up-to-date and thorough description of how epigenetic modifications in tumor cells influence immune cell responses in the tumor microenvironment.
    [Signal Transduction and Targeted Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    Rice, Baylor Developing ‘Glyco-Immune’ Checkpoint Inhibitor

    Researchers from Rice University and Baylor College of Medicine are hoping a first-of-its-kind “glyco-immune” checkpoint inhibitor could be the key to stopping bone cancer metastasis for breast cancer survivors.
    [Rice University]

    Press Release
    FEATURED EVENT

    ASM Microbe

    June 15 – 19, 2023
    Houston, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    PhD Student – Clinical Chemistry and Molecular Diagnostics

    University of Leipzig – Leipzig, Germany

    Postdoctoral Fellow – Viral Infections and Cancers

    UMass Chan Medical School – Worcester, Massachusetts, United States

    Postdoctoral Fellowship – Biomolecular Spectroscopy

    The University of British Columbia – Vancouver, British Columbia, Canada

    PhD Position – Tumor Tissue Engineering

    University of Lausanne – Lausanne, Switzerland

    Postdoctoral Scientist – Immunotherapy

    Max Delbrück Center for Molecular Medicine – Berlin, Germany

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Human Immunology News Twitter