 | | Vol. 11.23 – 13 June, 2023 |
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Researchers showed that agonists of α2-adrenergic receptors had very strong anti-tumor activity when used as monotherapies in multiple immunocompetent tumor models.
[Nature] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators explored drivers of fibroblast-like synoviocyte heterogeneity in inflamed joints of patients with rheumatoid arthritis using paired single-cell RNA and ATAC sequencing, multiplexed imaging, and spatial transcriptomics.
[Nature Immunology] |
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| The presence of concomitant colon tumors improved control of liver lesions by anti–PD-L1 proof-of-concept immunotherapy and generated protective immune memory, whereas partial depletion of α4β7+ cells abrogated control of metastases.
[Science Immunology] |
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| The authors showed comprehensive phenotyping in samples of circulating and tumor-resident B cells as well as serum antibodies in melanoma patients.
[Nature Communications] |
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| Researchers prepared, via a solid phase peptide synthesis approach, a modular tripartite vaccine candidate, incorporating a high-affinity glycocluster based on a tetraphenylethylene scaffold, to target the macrophage galactose-type lectin on antigen presenting cells.
[Journal Of The American Chemical Society] |
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| Scientists demonstrated that visualization of the translocator protein (TSPO) with DPA-714-PET-MRI revealed pronounced microglia activation and reactive gliosis in the hippocampus and amygdala of patients suspected with CD8 T cell autoimmune limbic encephalitis.
[Science Advances] |
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| The authors demonstrated that mucosal-associated invariant T cells are potent cytotoxic cells, rapidly degranulating, and inducing target cell death.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators analyzed human group 2 innate lymphoid cells (ILC2s) derived from different tissues and pathological conditions and identified ANXA1, encoding annexin A1, as a commonly highly expressed gene in non-activated ILC2s.
[Cell Reports] |
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| Scientists investigated the cellular anti-tumor reactivity of αβ T cells engineered to express a defined γδ TCR. developed a 3D cytotoxicity assay targeting cell line–derived spheroids.
[Journal Of Immunology] |
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| The authors review the evidence describing key cellular networks within and between the liver, gastrointestinal tract, and adipose tissue that control systemic metabolism and how these cell circuits become dysregulated during certain metabolic diseases.
[Immunity] |
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| Scientists discuss inflammaging at the molecular, cellular, organ, and disease levels and review current aging models, the implications of cutting-edge single-cell technologies, as well as anti-aging strategies.
[Signal Transduction And Targeted Therapy] |
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| Fred Hutch announced that Daniel Blanco-Melo, PhD and Lillian Cohn, PhD were the latest Fred Hutch scientists to benefit from highly competitive grant programs, which give a financial boost to promising, early-career scientists.
[Fred Hutchinson Cancer Center] |
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| July 2 – 7, 2023
Vaud, Switzerland |
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| | Karolinska Institutet – Solna, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | University College London – London, England, United Kingdom |
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| | Salk Institute – La Jolla, California, United States |
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| | MD Anderson Cancer Center – Houston, Texas, United States |
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