 | | Vol. 11.24 – 20 June, 2023 |
| |
|
|
| Scientists leveraged a neoadjuvant anti-PD-1 trial in patients with hepatocellular carcinoma, as well as additional samples collected from patients treated off-label, to explore correlates of response to immune checkpoint blockade within T cell-rich tumors.
[Nature Medicine] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators found that intact cancer cell-intrinsic expression of CD58 and ligation to CD2 was required for anti-tumor immunity and was predictive of treatment response.
[Cancer Cell] |
|
|
|
| Researchers elucidated the crystal structure of Sialic acid-binding Ig-like lectin 15 (Siglec-15) and its binding epitope via co-crystallization with an anti-Siglec-15 blocking antibody.
[Nature Communications] |
|
|
|
| Human innate immune macrophages were verified as essential to biomaterial rejection in the humanized mouse model and were capable of cross-talk with mouse fibroblasts for collagen matrix deposition.
[Science Advances] |
|
|
|
| The authors investigated the effect of both antimyeloperoxidase and antiproteinase 3 IgG on human monocytes.
[Journal of Autoimmunity] |
|
|
|
| Scientists investigated the effect of PFAS, short-chain, long-chain, and a mixture of both, on the in vitro activation of primary human immune cells.
[Chemosphere] |
|
|
|
| Researchers generated a stable B7-H3×PD-L1 bispecific antibody in IgG1-VHH format by coupling a humanized IgG1 monoclonal antibody against PD-L1 with a humanized camelus variable domain of the heavy-chain of heavy-chain antibody (VHH) against human B7-H3.
[Acta Pharmacologica Sinica] |
|
|
|
| The authors compared B cell subsets in human lungs versus circulating cells by analyzing patient-paired lung and blood samples.
[Journal of Immunology] |
|
|
|
| Scientists reported the development of a PDL1 × TIGIT bi-specific antibody GB265, a PDL1 × LAG3 bsAb GB266, and a PDL1 × TIGIT × LAG3 tri-specific antibody GB266T, all with intact Fc function.
[Scientific Reports] |
|
|
|
|
| Investigators summarize the current understanding of T cell development, CD4+ and CD8+ T cell classification, and differentiation in physiological settings.
[Signal Transduction and Targeted Therapy] |
|
|
|
| Scientists discuss the different types of senescent cells present in the tumor microenvironment (TME) and how these senescent cells and their senescence-associated secretory phenotype reshape the TME, affect immune responses, and influence cancer progression.
[Developmental Cell] |
|
|
|
|
| Immutep Limited, a clinical-stage biotechnology company developing novel LAG-3 immunotherapies for cancer and autoimmune disease, announced the grant of a new patent by the US Patent Office.
[Immutep Limited] |
|
|
|
| A Group Leader in the Monash Biomedicine Discovery Institute, Dr. Mifsud has been awarded funding of $130,000 from the Lungitude Foundation for research into immune system function in transplants.
[Monash University] |
|
|
|
| Two University of California San Francisco (UCSF) scientists have received Pew awards in the biomedical sciences for their work in immunology as part of a program that supports promising early-career investigators.
[The University of California San Francisco] |
|
|
|
|
| August 28 – 30, 2023
Santa Fe, New Mexico, United States |
|
|
|
|
|
| | VIB Center for Cancer Biology – Leuven, Belgium |
|
|
|
| | King’s College London – London, England, United Kingdom |
|
|
|
| | Karolinska Institutet – Solna, Sweden |
|
|
|
| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
|
|
|
| | Centre for Oncology and Immunology – Hong Kong, Hong Kong |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
