Human Immunology News Volume 11.25 | Jun 27 2023

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    2023-06-27 | HIN 11.25


    Human Immunology News by STEMCELL Technologies
    Vol. 11.24 – 27 June, 2023
    TOP STORY

    Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency

    To better understand the role of dedicator of cytokinesis 11 (DOCK11) in human immune-cell function and disease, scientists conducted genetic, immunologic, and molecular assays in four patients from four unrelated families.
    [New England Journal Of Medicine]

    Abstract
    Keep current with the latest in infectious disease research.
    PUBLICATIONSRanked by the impact factor of the journal

    NBEAL2 Deficiency in Humans Leads to Low CTLA-4 Expression in Activated Conventional T Cells

    Investigators showed a comprehensive interactome of NBEAL2 in primary T cells, based on mass spectrometry identification of altogether 74 protein association partners.
    [Nature Communications]

    Full Article

    NFAT and NF-κB Dynamically Co-Regulate TCR and CAR Signaling Responses in Human T Cells

    Researchers showed that two key pathways in T cell signaling, calcium/nuclear factor of activated T cells (NFAT) and protein kinase C/nuclear factor κB (NF-κB), integrated through a dynamic and combinatorial strategy to fine-tune T cell response genes.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Novel Nanoadjuvants Balance Immune Activation with Modest Inflammation: Implications for Older Adult Vaccines

    Cells from young and older adults were used to evaluate the effect of novel biomaterials on cytokine and chemokine secretion in comparison to standard immune activators such as lipopolysaccharide and PMA/ionomycin.
    [Immunity & Ageing]

    Full Article

    CD47 Blockade Ameliorates Autoimmune Vasculitis via Efferocytosis of Neutrophil Extracellular Traps

    Researchers determined whether pathogenic neutrophil extracellular traps in anti-neutrophil cytoplasmic antibody-associated vasculitis escape from efferocytosis via the CD47 signaling pathway, resulting in the development of necrotizing vasculitis.
    [JCI Insight]

    Abstract

    Neutrophils in STAT1 Gain-of-Function Have a Pro-Inflammatory Signature Which Is Not Rescued by JAK Inhibition

    The authors demonstrated that STAT1 gain-of-function human ex-vivo peripheral blood neutrophils were immature and highly activated; had strong propensity for degranulation, NETosis, and platelet-neutrophil aggregation; and displayed marked inflammatory bias.
    [Journal of Clinical Immunology]

    Full Article

    Human In Vitro-Induced IL-17A+ CD8+ T Cells Exert Pro-Inflammatory Effects on Synovial Fibroblasts

    Scientists expanded IL-17A+ CD8+ T cells from healthy donor peripheral blood mononuclear cell or bulk CD8+ T cell populations using an in vitro polarization protocol.
    [Clinical and Experimental Immunology]

    AbstractGraphical Abstract

    Single-Cell Raman Microscopy with Machine Learning Highlights Distinct Biochemical Features of Neutrophil Extracellular Traps and Necrosis

    Principal component analysis of Raman spectra from neutrophil extracellular traps clearly distinguished them from necrotic cells despite their similar morphology, demonstrating their fundamental molecular differences.
    [Scientific Reports]

    Full Article

    The Effect of Blocking Immune Checkpoints LAG-3 and PD-1 on Human Invariant Natural Killer T Cell Function

    Scientists tested whether the blockade of programmed cell-death-1 (PD-1) and/or lymphocyte-activation-gene-3 (LAG-3) could enhance invariant Natural Killer T (iNKT) cell function. Utilizing peripheral blood mononuclear cells from healthy donors, they assessed the LAG-3 and PD-1 expression on iNKT cells.
    [Scientific Reports]

    Full Article
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    REVIEWS

    Human Circulating and Tissue-Resident Memory CD8+ T Cells

    The authors provide a brief history of the field and summarize the biology of circulating and tissue-resident memory CD8+ T cells, which are ultimately responsible for effective immune surveillance.
    [Nature Immunology]

    Abstract

    Whole Tumor Cell-Based Vaccines: Tuning the Instruments to Orchestrate an Optimal Antitumor Immune Response

    Scientists provide and critically discuss recent evidence for different aspects associated with optimal immune responses required for the design of effective whole-tumor cell vaccines.
    [British Journal Of Cancer]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    ImmunoGenesis and Cancer Focus Fund Announce $4.5 Million Investment to Support First-in-Human Trial of IMGS-001 for Relapsed or Refractory Advanced Solid Tumors

    ImmunoGenesis announced that Cancer Focus Fund plans to invest $4.5 million to support the Phase Ia/Ib clinical trial of ImmunoGenesis’ lead candidate, IMGS-001.
    [ImmunoGenesis (PRNewswire)]

    Press Release
    FEATURED EVENT

    2023 Biomaterials and Tissue Engineering

    July 16 – 21, 2023
    Holderness, New Hampshire, United States

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    JOB OPPORTUNITIES

    Postdoctoral Scientist – Cancer Immunotherapy

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    Full Professor – T Cell Immunology

    University of Tübingen – Tübingen, Germany

    Postdoctoral Fellowship – Tumor Metastasis

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Associate – Tumor Virus and Innate Immunity

    University of Miami – Miami, Florida, United States

    Group Leader – Cancer Immunology

    VIB Center for Cancer Biology – Leuven, Belgium

    > See All Jobs

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