Human Immunology News Volume 11.26 | Jul 4 2023

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    2023-07-04 | HIN 11.26


    Human Immunology News by STEMCELL Technologies
    Vol. 11.26 – 4 July, 2023
    TOP STORY

    Single-Cell Multi-Omics of Mitochondrial DNA Disorders Reveals Dynamics of Purifying Selection across Human Immune Cells

    By profiling 206,663 cells, the authors revealed the dynamics of pathogenic mitochondrial DNA deletion heteroplasmy consistent with purifying selection and distinct metabolic vulnerabilities across T cell states in vivo and validated these observations in vitro.
    [Nature Genetics]

    AbstractPress Release
    PUBLICATIONSRanked by the impact factor of the journal

    Polymorphic KIR3DL3 Expression Modulates Tissue-Resident and Innate-Like T Cells

    The expression profile and biological function of KIR3DL3 remain somewhat elusive, so scientists searched extensively for KIR3DL3 transcripts, revealing highly enriched expression in γδ and CD8+ T cells rather than NK cells.
    [Science Immunology]

    AbstractPress Release

    IL-7 Receptor Signaling Drives Human B Cell Progenitor Differentiation and Expansion

    Researchers demonstrated that IL-7 receptor signaling has a crucial role in human B lymphopoiesis. IL-7 drove proliferation and expansion of early B cell progenitors, but not of pre-BII large cells.
    [Blood]

    Abstract

    Differentiation of IL-26+ TH17 Intermediates into IL-17A Producers via Epithelial Crosstalk in Psoriasis

    Scientists identified a population of blood TH17 intermediates that produced high levels of IL-26 and differentiated into IL-17A-producing TH17 cells upon TGF-β1 exposure.
    [Nature Communications]

    Full Article

    Single-Cell RNA Sequencing Reveals the Immunoregulatory Roles of PegIFN-α in Patients with Chronic Hepatitis B

    Investigators applied scRNA-seq to delineate the transcriptomic landscape of peripheral immune cells in chronic hepatitis B patients before and after PegIFN-α therapy.
    [Hepatology]

    AbstractGraphical Abstract

    CD25high Effector Regulatory T Cells Hamper Responses to PD-1 Blockade in Triple-Negative Breast Cancer

    Researchers found that an immunosuppressive triple-negative breast cancer microenvironment was marked by an imbalance between effector αβCD8+ T cells and regulator T cells (Tregs) harboring hallmarks of highly suppressive effector Tregs.
    [Cancer Research]

    Abstract

    Self-Programmed Dynamics of T Cell Receptor Condensation

    The authors identified a phase separation mechanism controlling dynamic T cell receptors (TCR) clustering and signaling. The TCR signaling component CD3ε chain could condensate with Lck kinase through phase separation to form TCR signalosomes for active antigen signaling.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    The Role of B Cells in Immune Cell Activation in Polycystic Ovary Syndrome

    Scientists demonstrated that B cells were not central mediators of polycystic ovary syndrome pathology and that their frequencies were altered as a direct effect of androgen receptor activation.
    [eLife]

    Abstract

    Higher CD4+CD40+ T Cells (Th40 Cells) Associate with Systemic Lupus Erythematosus Activity

    Flow cytometry was used to identify the percentage of Th40 cells in peripheral blood from 24 systemic lupus erythematosus (SLE) patients and 24 healthy individuals and the level of IL-2, IL-4, IL-6, IL-10, interferon-r, and tumor necrosis factor-α in serum from the SLE patients.
    [Scientific Reports]

    Full Article
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    REVIEWS

    Memory B Cells

    Investigators review the cellular and molecular mechanisms by which memory B cells are generated and how these processes shape the antibody diversity and breadth of memory B cells.
    [Nature Reviews Immunology]

    Abstract

    γδ T Cells and Allergic Diseases

    The authors review literature on the physical roles and functions of various subsets of γδ T cells, including type 1 T helper-like, type 2 T helper-like, and type 17 T helper-like γδ T cells.
    [Clinical Reviews in Allergy & Immunology]

    Abstract

    T Cell Cholesterol Accumulation, Aging, and Atherosclerosis

    Scientists review how pathways that regulate T cell cholesterol accumulation determine T cell fate, atherosclerosis, and T cell aging. The extent of T cell cholesterol accumulation and its cellular localization determine T cell fate and downstream effects on atherosclerosis and T cell functionality.
    [Current Atherosclerosis Reports]

    Full Article
    INDUSTRY AND POLICY NEWS

    Icahn School of Medicine at Mount Sinai Researchers Awarded $15.1 Million Grant to Explore Immune Rejection of Transplanted Organs

    Researchers in immunology and bioengineering at the Icahn School of Medicine at Mount Sinai have received $15.1 million from the National Institute of Allergy and Infectious Disease to lead a novel, five-year multi-center research program that will explore trained immunity.
    [Icahn School of Medicine at Mount Sinai]

    Press Release
    FEATURED EVENT

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    August 12 – 13, 2023
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    JOB OPPORTUNITIES

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    University of Wisconsin-Madison – Madison, Wisconsin, United States

    Postdoctoral Researcher – Inflammatory Conditions

    Maynooth University – Maynooth, Ireland

    Postdoctoral Scientist – Cancer Immunotherapy

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    Full Professor – T Cell Immunology

    University of Tübingen – Tübingen, Germany

    Postdoctoral Fellowship – Tumor Metastasis

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    > See All Jobs

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