Human Immunology News Volume 11.27 | Jul 11 2023

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    2023-07-11 | HIN 11.27


    Human Immunology News by STEMCELL Technologies
    Vol. 11.27 – 11 July, 2023
    TOP STORY

    Vaccine-Boosted CAR T Crosstalk with Host Immunity to Reject Tumors with Antigen Heterogeneity

    Researchers found that in vivo vaccine boosting of CAR T cells triggers the engagement of the endogenous immune system to circumvent antigen-negative tumor escape.
    [Cell]

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    Tips to prepare for your next conference or networking event
    PUBLICATIONSRanked by the impact factor of the journal

    3D Chromatin Reprogramming Primes Human Memory TH2 Cells for Rapid Recall and Pathogenic Dysfunction

    Investigators showed that human CD4+ memory T helper 2 (TH2) cells carry a chromatin landscape synergistically reprogrammed at both one-dimensional and 3D levels to accommodate recall responses, which was absent in naive T cells.
    [Science Immunology]

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    ARIH1 Activates STING-Mediated T Cell Activation and Sensitizes Tumors to Immune Checkpoint Blockade

    Using an immune checkpoint blockade-insensitive tumor model, researchers discovered that cisplatin enhanced the anti-tumor effect of PD-L1 blockade and upregulated the expression of Ariadne RBR E3 ubiquitin-protein ligase 1 (ARIH1) in tumors.
    [Nature Communications]

    Full Article

    Inflammatory and Tolerogenic Myeloid Cells Determine Outcome Following Human Allergen Challenge

    Scientists identified not only mononuclear phagocytic system (MPS) cell clusters involved in airway allergic inflammation but also highlighted novel roles for non-inflammatory innate MPS responses by myeloid-derived suppressor cells to allergens in non-allergic individuals.
    [Journal of Experimental Medicine]

    Full Article

    S100A5 Attenuates Efficiency of Anti-PD-L1/PD-1 Immunotherapy by Inhibiting CD8+ T Cell-Mediated Anti-Cancer Immunity in Bladder Carcinoma

    S100A5 shaped a non-inflamed tumor microenvironment in bladder cancer by inhibiting the secretion of pro-inflammatory chemokines and the recruitment and cytotoxicity of CD8+ T cells.
    [Advanced Science]

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    A Gain-of-Function Variation in PLCG1 Causes a New Immune Dysregulation Disease

    The authors investigated the molecular pathogenesis of a phospholipase C (PLC) G1 activating variant in a patient with immune dysregulation. Next-generation sequencing was used to identify the patient’s pathogenic variants.
    [Journal of Allergy and Clinical Immunology]

    Abstract

    A Prognostic Model Based on Residual Cancer Burden and Tumor-Infiltrating Lymphocytes on Residual Disease after Neoadjuvant Therapy in HER2+ Breast Cancer

    Researchers evaluated the prognostic significance of tumor-infiltrating lymphocyte on residual disease in HER2+ breast cancer patients who failed to achieve pathologic-complete response after anti-HER2+chemotherapy-based neoadjuvant treatment.
    [Clinical Cancer Research]

    Abstract

    A Nondepleting Anti-CD19 Antibody Impairs B Cell Function and Inhibits Autoimmune Diseases

    Scientists described a nondepleting, high-affinity anti–human CD19 antibody LY3541860 that exhibited potent B cell inhibitory activities. LY3541860 inhibited B cell activation, proliferation, and differentiation of primary human B cells with high potency.
    [JCI Insight]

    Full ArticleGraphical Abstract

    S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Anti-Tumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells

    Investigators developed a novel humanized anti-CCR8 monoclonal antibody, S-531011, aimed as a cancer immunotherapy strategy for patients with cancer.
    [Molecular Cancer Therapeutics]

    Abstract
    Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center
    REVIEWS

    Type 2 Immunity in the Brain and Brain Borders

    The authors discuss the beneficial and detrimental roles of type 2 immune cells and cytokines in central nervous system injury and homeostasis, cognition, and diseases such as tumors, Alzheimer’s disease, and multiple sclerosis.
    [Cellular & Molecular Immunology]

    Full Article

    Germinal Center-Dependent and -Independent Immune Responses of Tumor-Infiltrating B Cells in Human Cancers

    Investigators highlight the need for more integrative B cell immunology studies to rationally investigate tumor infiltrating B cells as a leverage for antitumor therapies.
    [Cellular & Molecular Immunology]

    Full Article

    Role of B Cells in Immune-Related Adverse Events following Checkpoint Blockade

    Scientists focus on the possible role of humoral immunity, specifically human B cell subsets and autoantibodies in the pathogenesis of immune checkpoint blockade-induced immune-related adverse events.
    [Immunological Reviews]

    Abstract
    INDUSTRY AND POLICY NEWS

    HI-Bio Initiates Healthy Volunteer Study of HIB210 for Immune-Mediated Diseases

    Human Immunology Biosciences (HI-Bio™) announced that the first participants have been dosed in a Phase I healthy volunteer study of HIB210, an investigational monoclonal antibody targeting C5aR1.
    [Human Immunology Biosciences]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Faculty Positions – Advanced Immunochemical Studies

    ShanghaiTech University – Shanghai, China

    Postdoctoral Position – Immune Modulation in Cancer and Microbiome

    The Hospital of the University of Munich – Munich, Germany

    Postdoctoral Fellow – Tumor Microenvironment

    The University of Texas MD Anderson Cancer Center- Houston, Texas, United States

    Postdoctoral Scientist – Tumor Immunology and Radio-Immunotherapy

    University of Alabama at Birmingham – Birmingham, Alabama, United States

    Faculty Position – Adaptive Immune System

    University of Tübingen – Tübingen, Germany

    > See All Jobs

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