Human Immunology News Volume 11.28 | Jul 18 2023

July 18, 2023

2023-07-18 | HIN 11.28

Human Immunology News by STEMCELL Technologies

Vol. 11.28 – 18 July, 2023

TOP STORY

A Distinct Stimulatory cDC1 Subpopulation Amplifies CD8⁺ T Cell Responses in Tumors for Protective Anti-Cancer Immunity

Investigators used imaging-based deep learning to identify intratumoral type 1 conventional dendritic cells (cDC1)-CD8⁺ T cell clustering as a unique feature of protective anti-cancer immunity.
[Cancer Cell]

Full Article Graphical Abstract

View tips on how to choose efficient technologies for your research.

PUBLICATIONSRanked by the impact factor of the journal

Induction of Bronchus-Associated Lymphoid Tissue Is an Early Life Adaptation for Promoting Human B Cell Immunity

Researchers showed that bronchus-associated lymphoid tissue, containing B cell follicles, CD4⁺ T cells and functionally active germinal centers, develop during infancy.
[Nature Immunology]

Abstract Press Release

A Three-Stage Developmental Pathway for Human Vγ9Vδ2 T Cells within the Postnatal Thymus

The authors used high-dimensional flow cytometry, transcriptomic analysis, functional assays, and precursor-product experiments to define the development pathway of Vγ9Vδ2 T cells in the postnatal thymus.
[Science Immunology]

Abstract Press Release

Gluten Induces Rapid Reprogramming of Natural Memory αβ and γδ Intraepithelial T Cells to Induce Cytotoxicity in Celiac Disease

Investigators performed multiplexed single-cell analysis of intestinal and gluten-induced peripheral blood T cells from patients in different celiac disease states and healthy controls.
[Science Immunology]

Full Article

Multimodal Immune Cell Phenotyping in GI Biopsies Reveals Microbiome-Related T Cell Modulations in Human GvHD

Scientists highlighted the pathophysiological importance of expanded CD8 T cell clones in the progression of acute graft-versus-host disease (GvHD) toward more severe clinical manifestations.
[Cell Reports Medicine]

Full Article Graphical Abstract

Low Level of ARID1A Contributes to Adaptive Immune Resistance and Sensitizes Triple-Negative Breast Cancer to Immune Checkpoint Inhibitors

The authors evaluated the role of ARID1A among a series of epigenetic modulators in triple-negative breast cancer and explored how low ARID1A expression contributed to adaptive immune resistance.
[Cancer Communications]

Full Article

Accumulation of Tissue-Resident Natural Killer Cells, Innate Lymphoid Cells, and CD8⁺ T Cells towards the Center of Human Lung Tumors

Scientists identified an accumulation of tissue-resident lymphocytes including tissue-resident NK cells and CD8⁺ tissue-resident memory T cells toward the center of human non-small cell lung carcinomas.
[OncoImmunology]

Full Article

Human Granzyme K Is a Feature of Innate T Cells in Blood, Tissues, and Tumors, Responding to Cytokines Rather Than TCR Stimulation

Researchers showed that, in humans, granzyme K (GzmK) was predominantly expressed by innate-like lymphocytes, as well as a newly identified population of GzmK⁺CD8⁺ non– mucosal-associated invariant T cells with innate-like characteristics.
[Journal of Immunology]

Abstract

Human β-Defensins Are Correlated with the Immune Infiltration and Regulated by Vitamin D₃ in Periodontitis

Investigators explored the correlation between human β-defensins and immune infiltration in periodontitis and determined whether it is regulated by vitamin D₃.
[Journal Of Periodontal Research]

Abstract

Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.

REVIEWS

Resistance to Immune Checkpoint Therapies by Tumour-Induced T Cell Desertification and Exclusion: Key Mechanisms, Prognostication, and New Therapeutic Opportunities

The authors dive into critical mechanisms by which cancer cells induce T cell ‘desertification’ and ‘exclusion’ in immune checkpoint therapies refractory tumors.
[British Journal of Cancer]

Full Article

Human Neutrophil Fc Gamma Receptors: Different Buttons for Different Responses

Investigators describe the major Fcγ receptors expressed on human neutrophils and discuss how each Fcγ receptor activates a choice of signaling pathways to stimulate particular neutrophil responses.
[Journal of Leukocyte Biology]

Abstract

Insight on Immune Cells in Rejection and Infection Postlung Transplant

Scientists provide a concise overview of the role of immune cells in rejection and infection after lung transplantation.
[Immunity Inflammation And Disease]

Full Article

INDUSTRY AND POLICY NEWS

Allen Institute for Immunology Partners with Lilly to Better Understand Autoimmune Disease

The Allen Institute for Immunology has announced that researchers and staff will collaborate with private industry researchers to aid in the detailed, molecular understanding of disease, in service of developing new treatments and therapies to improve human health.
[Allen Institute]

Press Release

UB, Partner Awarded $3 Million NIH Grant to Study Immune Cell Therapy for Tumors

The National Cancer Institute awarded Dr. Ruogang Zhao, professor of biomedical engineering at the University at Buffalo (UB), and a colleague a five-year, $3 million R01 research grant to study immune cell therapy for solid tumors.
[University at Buffalo]

Press Release

FEATURED EVENT

Human Immunology News Volume 11.28 | Jul 18 2023

A Distinct Stimulatory cDC1 Subpopulation Amplifies CD8⁺ T Cell Responses in Tumors for Protective Anti-Cancer Immunity

Induction of Bronchus-Associated Lymphoid Tissue Is an Early Life Adaptation for Promoting Human B Cell Immunity

A Three-Stage Developmental Pathway for Human Vγ9Vδ2 T Cells within the Postnatal Thymus

Gluten Induces Rapid Reprogramming of Natural Memory αβ and γδ Intraepithelial T Cells to Induce Cytotoxicity in Celiac Disease

Multimodal Immune Cell Phenotyping in GI Biopsies Reveals Microbiome-Related T Cell Modulations in Human GvHD

Low Level of ARID1A Contributes to Adaptive Immune Resistance and Sensitizes Triple-Negative Breast Cancer to Immune Checkpoint Inhibitors

Accumulation of Tissue-Resident Natural Killer Cells, Innate Lymphoid Cells, and CD8⁺ T Cells towards the Center of Human Lung Tumors

Human Granzyme K Is a Feature of Innate T Cells in Blood, Tissues, and Tumors, Responding to Cytokines Rather Than TCR Stimulation

Human β-Defensins Are Correlated with the Immune Infiltration and Regulated by Vitamin D₃ in Periodontitis

Resistance to Immune Checkpoint Therapies by Tumour-Induced T Cell Desertification and Exclusion: Key Mechanisms, Prognostication, and New Therapeutic Opportunities

Human Neutrophil Fc Gamma Receptors: Different Buttons for Different Responses

Insight on Immune Cells in Rejection and Infection Postlung Transplant

Allen Institute for Immunology Partners with Lilly to Better Understand Autoimmune Disease

UB, Partner Awarded $3 Million NIH Grant to Study Immune Cell Therapy for Tumors

2023 Lung Development, Injury, and Repair Seminar GRC

> See All Events

Executive Medical Director – Radiopharmaceuticals

Postdoctoral Fellow – Tumor Microenvironment in Gastrointestinal and Liver Cancer

Faculty Positions – Advanced Immunochemical Studies

Postdoctoral Position – Immune Modulation in Cancer and Microbiome

Postdoctoral Fellow – Tumor Microenvironment

> See All Jobs