Human Immunology News Volume 11.29 | Jul 25 2023

July 25, 2023

2023-07-25 | HIN 11.29

Human Immunology News by STEMCELL Technologies

Vol. 11.29 – 25 July, 2023

TOP STORY

Systematic Single Amino Acid Affinity Tuning of CD229 CAR T Cells Retains Efficacy against Multiple Myeloma and Eliminates On-Target Off-Tumor Toxicity

To increase the selectivity of CD229 CAR T cells for multiple myeloma cells, scientists used a single amino acid substitution approach of the CAR binding domain to reduce CAR affinity.
[Science Translational Medicine]

Abstract Press Release

Explore scientific resources for your immunology research at the STEMCELL Technologies immunology learning center

PUBLICATIONSRanked by the impact factor of the journal

Tumor-Derived GDF-15 Blocks LFA-1 Dependent T Cell Recruitment and Suppresses Responses to Anti-PD-1 Treatment

Researchers showed that the cytokine growth/differentiation factor-15 (GDF-15) impaired leukocyte function-associated antigen (LFA)−1 /β2-integrin-mediated adhesion of T cells to activated endothelial cells, which was a pre-requisite of T cell extravasation.
[Nature Communications]

Full Article Press Release

TOX2 Coordinates with TET2 to Positively Regulate Central Memory Differentiation in Human CAR T Cells

The authors showed that loss of Tet methylcytosine dioxygenase 2 (TET2) led to increased chromatin accessibility at exhaustion regulators thymocyte selection-associated high mobility group box protein (TOX) and TOX2, plus increased expression of TOX2.
[Science Advances]

Full Article

Inhibition of Complement C3 Signaling Ameliorates Locomotor and Visual Dysfunction in Autoimmune Inflammatory Diseases

Using the targeted C3 inhibitor CR2-Crry led to a significant decrease in complement deposition and demyelination in both slice cultures and focal intracerebral injection models.
[Molecular Therapy]

Abstract Graphical Abstract

Redefining the Human Corneal Immune Compartment Using Dynamic Intravital Imaging

Scientists developed functional in vivo confocal microscopy to investigate immune cell dynamics in the human corneal epithelium and stroma.
[Proceedings Of The National Academy Of Sciences Of The United States Of America]

Abstract Press Release

The Expression Profiles of Signature Genes from CD103⁺LAG3⁺ Tumor-Infiltrating Lymphocyte Subsets Predict Breast Cancer Survival

Investigators identified two tumor-infiltrating lymphocytes subsets with high expression of CD103 and LAG3, including a CD8⁺ T cell subset and a B cell subset.
[BMC Medicine]

Full Article

Neutrophil Extracellular Traps Promote Angiogenesis in Gastric Cancer

The authors determined the role of neutrophil extracellular traps (NETs) in promoting angiogenesis in gastric cancer. Multiple immunohistochemical staining was used to analyze the spatial distribution of NETs and microvessels in patient tissue samples.
[Cell Communication and Signaling]

Full Article Graphical Abstract

The mRNA Expression and Secretion of Granzyme B Are Up-Regulated via the Histamine H2 Receptor in Human CD4⁺ T Cells

Investigators evaluated naïve CD4⁺ T cells polarized into Th2 cells, total CD4⁺ T cells treated with IL-4 for 72 h, and CD4⁺ T cells isolated from healthy donors and atopic dermatitis patients.
[Inflammation Research]

Full Article

TGF-β Signaling Prevents MHC Class II–Expressing Lymphatic Endothelial Cells from Reactivating Human Allogenic Memory CD4⁺ T Cells

Scientists showed that IFN-γ–activated human dermal lymphatic endothelial cells could robustly reactivate allogeneic human memory CD4⁺ T cells, but only when TGF-β signaling was inhibited.
[Journal of Immunology]

Abstract

In Vitro Model to Mimic T Cell Subset Change in Human PDAC Organoid Co-Culture

Researchers evaluated changes in T cell subtypes upon co-culture of patient-derived pancreatic ductal adenocarcinoma organoids and matched peripheral blood mononuclear cells.
[Journal of Cancer Research and Clinical Oncology]

Full Article

REVIEWS

The Emerging Family of RORγt⁺ Antigen-Presenting Cells

The authors summarize the major findings that led to the discovery of RORγt⁺ antigen-presenting cells and their associated functions, discuss discordance in recent reports, and identify gaps in knowledge in this burgeoning field.
[Nature Reviews Immunology]

Abstract

Biomaterials for In Situ Cell Therapy

Investigators summarize recent advances in biomaterials for in situ cell therapy including T cells, macrophages, dendritic cells, and stem cells reprogramming leveraging lipid nanoparticles, polymers, inorganic materials, and other biomaterials.
[BMEMat]

Full Article

INDUSTRY AND POLICY NEWS

Replay and MD Anderson Announce FDA Clearance of IND Application for First-in-Class T Cell Receptor Natural Killer (TCR-NK) Cell Therapy for Multiple Myeloma

Replay and The University of Texas MD Anderson Cancer Center announced that the US FDA has issued a ‘safe to proceed’ for the Investigational New Drug (IND) application for NY-ESO-1 TCR/IL-15 NK, a first-in-class engineered TCR-NK cell therapy for relapsed or refractory multiple myeloma.
[Replay Bio]

Press Release

FEATURED EVENT

Human Immunology News Volume 11.29 | Jul 25 2023

Systematic Single Amino Acid Affinity Tuning of CD229 CAR T Cells Retains Efficacy against Multiple Myeloma and Eliminates On-Target Off-Tumor Toxicity

Tumor-Derived GDF-15 Blocks LFA-1 Dependent T Cell Recruitment and Suppresses Responses to Anti-PD-1 Treatment

TOX2 Coordinates with TET2 to Positively Regulate Central Memory Differentiation in Human CAR T Cells

Inhibition of Complement C3 Signaling Ameliorates Locomotor and Visual Dysfunction in Autoimmune Inflammatory Diseases

Redefining the Human Corneal Immune Compartment Using Dynamic Intravital Imaging

The Expression Profiles of Signature Genes from CD103⁺LAG3⁺ Tumor-Infiltrating Lymphocyte Subsets Predict Breast Cancer Survival

Neutrophil Extracellular Traps Promote Angiogenesis in Gastric Cancer

The mRNA Expression and Secretion of Granzyme B Are Up-Regulated via the Histamine H2 Receptor in Human CD4⁺ T Cells

TGF-β Signaling Prevents MHC Class II–Expressing Lymphatic Endothelial Cells from Reactivating Human Allogenic Memory CD4⁺ T Cells

In Vitro Model to Mimic T Cell Subset Change in Human PDAC Organoid Co-Culture

The Emerging Family of RORγt⁺ Antigen-Presenting Cells

Biomaterials for In Situ Cell Therapy

Replay and MD Anderson Announce FDA Clearance of IND Application for First-in-Class T Cell Receptor Natural Killer (TCR-NK) Cell Therapy for Multiple Myeloma

4^th International Conference on Lymphocyte Engineering

> See All Events

PhD Candidate – Tumor Microenvironment Reprogramming

Research Associate – T Cell Therapeutics

Faculty Positions – Advanced Immunochemical Studies

Postdoctoral Fellow – Tumor Microenvironment in Gastrointestinal and Liver Cancer

Postdoctoral Position – Immune Modulation in Cancer and Microbiome

> See All Jobs