Human Immunology News Volume 11.30 | Aug 1 2023

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    2023-08-01 | HIN 11.30


    Human Immunology News by STEMCELL Technologies
    Vol. 11.30 – 1 August, 2023
    TOP STORY

    CTLA-4 Tail Fusion Enhances CAR-T Antitumor Immunity

    Utilizing the endocytic feature of the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) cytoplasmic tail, researchers reprogramed CAR function and substantially enhanced CAR-T efficacy in vivo.
    [Nature Immunology]

    AbstractPress Release
    Cell Preparation For Crossmatch Assays
    PUBLICATIONSRanked by the impact factor of the journal

    Clonally Expanded CD38hi Cytotoxic CD8 T Cells Define the T Cell Infiltrate in Checkpoint Inhibitor–Associated Arthritis

    Scientists compared T cells from the joints of 20 patients with an inflammatory arthritis induced by immune checkpoint inhibitor therapy with two archetypal autoimmune arthritides, rheumatoid arthritis and psoriatic arthritis.
    [Science Immunology]

    AbstractPress Release

    Ezh2 Emerges as an Epigenetic Checkpoint Regulator during Monocyte Differentiation Limiting Cardiac Dysfunction Post-MI

    Researchers demonstrated that Enhancer of zeste homolog 2 (Ezh2) served as an epigenetic checkpoint regulator during monocyte to macrophage differentiation.
    [Nature Communications]

    Full Article

    Single-Cell Profiling of Muscle-Infiltrating T Cells in Idiopathic Inflammatory Myopathies

    Investigators performed in-depth single-cell sequencing on muscle-infiltrating T cells and peripheral blood memory T cells in six patients with recently diagnosed idiopathic inflammatory myopathies.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Targeting the Immunoglobulin IGSF9 Enhances Anti-Tumor T Cell Activity and Sensitivity to Anti-PD-1 Immunotherapy

    Researchers identified increased expression of the adhesion molecule immunoglobulin superfamily member 9 (IGSF9) in tumor cells and tumor-infiltrating immune cells across multiple cancer types.
    [Cancer Research]

    Abstract

    Genetically Stable and Scalable Nanoengineering of Human Primary T Cells via Cell Mechanoporation

    Investigators developed a nonviral T cell nanoengineering system that allowed highly efficient delivery of diverse functional nanomaterials into primary human T cells in a genetically stable and scalable manner.
    [Nano Letters]

    AbstractGraphical Abstract

    SLC15A4 Controls Endolysosomal TLR7–9 Responses by Recruiting the Innate Immune Adaptor TASL

    The authors showed that the critical role of solute carrier family 15 member 4 (SLC15A4) in endolysosomal toll-like receptor (TLR) 7–9 responses was to mediate lysosomal recruitment of TASL.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Engineered Artificial Human Neutrophils Exhibit Mature Functional Performance

    Investigators combined genetic engineering technology with a nanodrug system to construct artificial neutrophils that displayed functions similar to those of native neutrophils.
    [ACS Synthetic Biology]

    AbstractGraphical Abstract

    GM-CSF Distinctly Impacts Human Monocytes and Macrophages via ERK1/2-Dependent Pathways

    The authors compared the effects of GM-CSF on the expression of several immune mediators by human monocytes and monocyte-derived macrophages obtained from healthy donors.
    [Immunology Letters]

    Abstract
    Explore the Science Events Calendar to discover conferences, podcasts, webinars, and more!
    REVIEWS

    Type 2 Chronic Inflammatory Diseases: Targets, Therapies, and Unmet Needs

    Scientists review common targets, current treatments, and emerging therapies for the treatment of five major type 2 chronic inflammatory diseases.
    [Nature Reviews Drug Discovery]

    Abstract
    INDUSTRY AND POLICY NEWS

    Senate Panel Approves 2% Bump for NIH Budget in 2024

    Although below the rate of biomedical inflation, it is far more generous than a corresponding House of Representatives bill that would slash NIH’s budget by 6%.
    [Science Insider]

    Press Release
    FEATURED EVENT

    17th Vaccine Congress

    September 24 – 27, 2023
    Glasgow, Scotland

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    JOB OPPORTUNITIES

    Research Assistant – Biomedicine

    IRB Barcelona – Barcelona, Spain

    Postdoctoral Position – HIV Persistence and Neuroimmunology

    University of California, Berkeley – Berkeley, California, United States

    Postdoctoral Research Fellow – Role of AHR in Mediating Barrier Tissue Homeostasis

    Harvard Medical School – Boston, Massachusetts, United States

    Research Associate – T Cell Therapeutics

    City of Hope – Duarte, California, United States

    PhD Candidate – Tumor Microenvironment Reprogramming

    The University Hospital Essen – Essen, Germany

    > See All Jobs

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