 | | Vol. 11.31 – 8 August, 2023 |
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| Investigators determined IL-3 expression in samples from patients with inflammatory bowel disease and studied the impact of Il3 or Il3r deficiency on T cell-dependent experimental colitis.
[Gut] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that both wild-type and interleukin-2 receptor-β/interleukin-2 receptor-γ (IL-2Rβγ)-attenuated agonists that preserved IL-2Rα activities could effectively expand tumor-specific CD8+ T cells.
[Nature Cancer] |
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| Scientists described CAR T cells targeting tumor-associated glycoprotein-72, utilizing the CD28 transmembrane domain upstream of the 4-1BB co-stimulatory domain as a driver of potent anti-tumor activity and interferon gamma secretion.
[Nature Communications] |
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| The authors measured the immune cell transcriptional profile of paired lower esophageal sphincter tissue and blood samples in achalasia and controls using single-cell RNA sequencing.
[Nature Communications] |
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| Researchers investigated the targetability of neoantigens in advanced progessive melanoma and explored the potential for continued T cell-based immunotherapy.
[Clinical Cancer Research] |
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| The authors tested whether the effector molecules expressed in microglia/macrophages were involved in schizophrenia via regulating stress susceptibility.
[BMC Medicine] |
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| Investigators evaluated the associations among the expressions of HER2, cyclic GMP–AMP synthase–STING, and the number of CD8+ tumor-infiltrating lymphocytes by considering HER2 heterogeneity in HER2-positive gastric cancer tissues.
[Gastric Cancer] |
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| To investigate the effect of PI3K p110δ inhibition in the production of human IgE, scientists isolated human B cells from tonsil tissue and stimulated them with IL-4 and anti-CD40 antibody to induce class switching to IgE and IgG1 in the presence or absence of IC87114.
[Immunology] |
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| Researchers explored whether macrophage functions in healthy individuals and acute myeloid leukemia patients were influenced by tumor suppressor cylindromatosis (CYLD).
[PLOS One] |
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| Scientists review studies showing that skin-derived αβ T cells directly recognize CD1a proteins, and certain bound lipids, such as contact dermatitis allergens, trigger T cell responses.
[European Journal of Immunology] |
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| Endowed by long-time Fred Hutch supporters Ric and Kaylene Anderson, the chair will provide Dr. Aaron Ring with sustained support as he untangles the immune system’s complexities and uses immuno-pharmacological approaches to develop cancer immunotherapies.
[Fred Hutchinson Cancer Center] |
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| September 20 – 23, 2023
Milan, Italy |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Center for Excellence in Molecular Cell Science – Shanghai, China |
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| | IRB Barcelona – Barcelona, Spain |
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| | University of California, Berkeley – Berkeley, California, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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