 | | Vol. 11.33 – 22 August, 2023 |
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| Scientists did a complete phenotyping of two pig kidney xenografts transplanted to decedent humans, using a multimodal strategy combining morphological evaluation, immunophenotyping, gene expression profiling, and whole-transcriptome digital spatial profiling and cell deconvolution.
[Lancet] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| IFNε activated anti-tumor T and natural killer cells and prevented the accumulation and activation of myeloid-derived suppressor cells and regulatory T cells.
[Nature] |
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| To depict NK cells’ phenotypic and functional diversities in the tumor microenvironment, researchers performed integrative single-cell RNA sequencing analyses on NK cells from 716 patients with cancer, covering 24 cancer types.
[Cell] |
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| The authors reported on the modular and programmable assembly of IgG antibodies, F(ab) and scFv fragments on DNA origami nanocarriers.
[Nature Nanotechnology] |
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| Bulk RNA-seq of sorted human exTreg cells identified them as inflammatory and cytotoxic CD4+T cells that were significantly distinct from both natural killer and Treg cells.
[Nature Immunology] |
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| By analysing lymphocytes from matched human tumor and peripheral blood samples, investigators showed that TIGIT and CD226 co-expression was rare on tumor-infiltrating lymphocytes.
[Nature Communications] |
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| Scientists measured T cell bispecific antibodies-mediated CD8+ T cell activation and killing of RMF- human leukocyte antigen-A2-presenting cells in the presence of peripheral blood mononuclear cells and multiple tool compounds.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors studied the role of early innate cytokines (IFNα) and late immune adaptive events (IFNɣ) in insulin defective ribosomal products-derived peptide presentation to diabetogenic CD8+ T cells.
[Diabetologia] |
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| Investigators identified age-associated DNA methylation sites in six purified blood borne immune cell types, naïve B, naïve CD4+ and CD8+ T cells, granulocytes, monocytes and NK cells, collected from healthy individuals interspersed over a wide age range.
[eLife] |
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| Scientists examine advances in clinical and scientific knowledge gleaned from studies in select cancers and describe emerging key principles relevant to neoadjuvant immune checkpoint blockade across many cancer types.
[Cancer Cell] |
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| The authors review technical issues that compromise single cell analysis of tissue macrophages including limited and unrepresentative yields, fragmentation and generation of remnants, and activation during tissue disaggregation.
[Blood] |
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| Regeneron has scored an FDA nod for Veopoz as the first treatment for the ultra-rare inherited immune condition Chaple disease. The disease, which is also known as CD55-deficient protein-losing enteropathy, has a global patient population of fewer than 100 people.
[Fierce Pharma (Regeneron)] |
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| September 20 – 23, 2023
EMBL Heidelberg and Virtual |
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| | University of Regensberg – Heidelberg, Germany |
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| | The Scripps Research Institute – La Jolla, California, United States |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Technical University of Denmark – Kongens Lyngby, Denmark |
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