Human Immunology News Volume 11.34 | Aug 29 2023

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    Laurisa Dohm
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    2023-08-29 | HIN 11.34


    Human Immunology News by STEMCELL Technologies
    Vol. 11.34 – 29 August, 2023
    TOP STORY

    Early B Cell Development and B Cell Maturation Are Impaired in Patients with Active Hemophagocytic Lymphohistiocytosis

    Researchers noted marked suppression of early B cell development in patients with active hemophagocytic lymphohistiocytosis (HLH). In vitro B cell differentiation studies following exposure to HLH-defining cytokines, such as interferon-gamma and tumor necrosis factor, recapitulated B cell development arrest.
    [Blood]

    Abstract
    Histocompatibility testing needed standardization. So he developed the protocols. Read Robert Liwski's profile.
    PUBLICATIONSRanked by the impact factor of the journal

    FcγRIIB Expressed on CD8+ T Cells Limits Responsiveness to PD-1 Checkpoint Inhibition in Cancer

    Scientists showed that despite exhibiting strong proliferative and cytokine responses at baseline, human FcγRIIBpos CD8+ T cells exhibited reduced responsiveness to both PD-1 and CTLA-4 checkpoint inhibition as compared with FcγRIIBneg CD8+ T cells in vitro.
    [Science Translational Medicine]

    Abstract

    IL-6 Translation Is a Therapeutic Target of Human Cytokine Release Syndrome

    Metoprolol effectively blocked IL-6 production in human monocytes through unexpected mechanisms of action of targeting IL-6 protein translation, but not IL6 mRNA expression.
    [Journal Of Experimental Medicine]

    Abstract

    Multi-Modal Single Cell Sequencing of B Cells in Primary Sjögren’s Syndrome

    Over 230,000 B cells were isolated from peripheral blood of primary Sjögren’s syndrome patients and four healthy controls, and processed for single cell RNA and VDJ sequencing.
    [Arthritis & Rheumatology]

    Abstract

    Activated Leukocyte Cell Adhesion Molecule on Human Oligodendrocytes Mediates CD4 T Cell Adhesion

    Investigators found that activated leukocyte cell adhesion molecule was a ligand for Th17-polarized cells, contributing to their capacity to adhere and induce damage to human oligodendrocytes.
    [Brain]

    Abstract

    Exposure of Volunteers to Microgravity by Dry Immersion Bed Over 21 Days Results in Gene Expression Changes and Adaptation of T Cells

    For safe space missions for crew members, it is important to understand the impact of space flight on the immune system. Researchers studied the effects of 21 days dry immersion exposure on the transcriptomes of T cells isolated from blood samples of eight healthy volunteers.
    [Science Advances]

    Full ArticlePress Release

    Fatty Acids Support the Fitness and Functionality of Tumor Resident CD8+ T Cells by Maintaining SCML4 Expression

    Scientists found that the transcription factor SCML4 was required for the progression and polyfunctionality of CD8+ tissue-resident memory T cells and was associated with a better prognosis in patients with cancer.
    [Cancer Research]

    Abstract

    Chemerin Triggers Migration of a CD8 T Cell Subset with Natural Killer Cell Functions

    The authors showed that subsets of human CD28- effector CD8 T cells, of CCR7- CD45RO+ effector memory and CCR7- CD45RO- effector memory RA phenotypes, expressed the chemerin receptor CMKLR1 and bound chemerin via the receptor.
    [Molecular Therapy]

    AbstractFull ArticleGraphical Abstract

    Glycoproteome Remodeling and Organelle-Specific N-Glycosylation Accompany Neutrophil Granulopoiesis

    Investigators comprehensively profilde the neutrophil N-glycoproteome with spatiotemporal resolution by analyzing four key types of intracellular organelles isolated from blood-derived neutrophils and during their maturation from bone marrow–derived progenitors using a glycomics-guided glycoproteomics approach.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract
    Science is demanding. That's why scientists work smart.
    REVIEWS

    Immune Checkpoint Therapy for Solid Tumours: Clinical Dilemmas and Future Trends

    Scientists enumerate the mechanisms of each immune checkpoint targets, associations between immune-checkpoint inhibitors with tumor mutation burden, key immune regulatory or resistance signalling pathways, and more.
    [Signal Transduction And Targeted Therapy]

    Full Article

    Who Wins the Combat, CAR or TCR?

    The authors discuss the parallel comparisons between CARs and T cell receptors (TCRs) from various aspects and how these current findings might provide novel insights and contribute to the improvement of CAR-T cell therapy efficacy.
    [Leukemia]

    Abstract
    INDUSTRY AND POLICY NEWS

    European Commission Approves TALVEY® (talquetamab), Janssen’s Novel Bispecific Therapy for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma

    Talquetamab is a bispecific T cell engaging antibody that binds to CD3, on the surface of T cells, and G protein-coupled receptor class C group 5 member D, a novel target expressed on the surface of multiple myeloma cells and hard keratinised tissues, with minimal to no expression detected on B cells and B cell precursors.
    [Janssen Pharmaceutical Companies of Johnson & Johnson]

    Press Release
    FEATURED EVENT

    AACR Special Conference: Pancreatic Cancer

    September 27 – 30, 2023
    Boston, Massachusetts, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Tumor Immunology

    National Cancer Institute – Bethesda, Maryland, United States

    Faculty Positions – Immunology & Microbiology

    The Scripps Research Institute – La Jolla, California, United States

    Professorship – Immune Cell & Tissue Interactions

    University of Regensberg – Heidelberg, Germany

    Postdoctoral Position – Engineering of iPSC-NK cells

    Technical University of Denmark – Kongens Lyngby, Denmark

    Postdoctoral Position – HIV Persistence and Neuroimmunology

    University of California, Berkeley – Berkeley, California, United States

    > See All Jobs

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