 | | Vol. 11.36 – 12 September, 2023 |
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Researchers investigated the impact of multicellular spatial organization on response and explored how immune checkpoint blockade remodeled the tumor microenvironment.
[Nature] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed how—in both humans and alpaca—multiple phosphoantigens functioned as ‘molecular glues’ to promote heteromeric association between the intracellular domains of BTN3A1 and the structurally similar butyrophilin BTN2A1.
[Nature] |
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| Using two systematic approaches, researchers revealed that CKLF like MARVEL transmembrane domain containing 6 (CMTM6) positively regulated CD58 expression.
[Cancer Cell] |
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| Using a novel enzymatic inhibitor of the RNA methyltransferase METTL3, the authors demonstrated that a global decrease in N6-methyladenosine resulted in double-stranded RNA formation and a profound cell-intrinsic interferon response.
[Cancer Discovery] |
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| Investigators identified reinvigoration of cytotoxicity among ZNF683+CD8+ T cells as a likely mechanism underlying response to neoadjuvant anti–PD-1 in head and neck cancer.
[Science Immunology] |
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| Researchers used precision CRISPR/Cas9 gene editing to engineer a “mousified” version of one such host protein, cyclin T1, in human T cells.
[mBio] |
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| Scientists evaluated the expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1), CD31, and immune cell markers in samples surgically resected from 11 ulcerative colitis patients with dysplasia/colitic cancer and 17 patients with sporadic colorectal cancer.
[International Journal of Cancer] |
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| Investigators showed that intra-epithelial CD8+ T cells were significantly more abundant in anti-PD-1 ± anti-CTLA-4-induced colitis compared to anti-CTLA-4-induced colitis and ulcerative colitis.
[iScience] |
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| The authors discovered that IL18 receptor accessory protein (IL18RAP) was related to the human tumor microenvironment and promotes various immune cell infiltration.
[Aging] |
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| Scientists present a framework wherein distinct innate immune signaling pathways activate five key dendritic cell activities that are important for T cell-mediated immunity.
[Immunity] |
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| The UK government announced that it will rejoin the European Union’s €95 billion research funding program known as Horizon Europe.
[ScienceInsider] |
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| October 5 – 7, 2023
Boston, Massachusetts, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Northwestern University – Chicago, Illinois, United States |
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| | National Cancer Institute – Bethesda, Maryland, United States |
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| | University of Regensberg – Heidelberg, Germany |
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| | Cedars-Sinai – Los Angeles, California, United States |
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