Human Immunology News Volume 11.37 | Sep 19 2023

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    2023-09-19 | HIN 11.37


    Human Immunology News by STEMCELL Technologies
    Vol. 11.37 – 19 September, 2023
    TOP STORY

    Conserved γδ T Cell Selection by BTNL Proteins Limits Progression of Human Inflammatory Bowel Disease

    Using mucosal samples obtained at colonoscopy from more than 150 individuals, scientists characterized the healthy human gut γδ T cell population.
    [Science]

    AbstractPress ReleaseGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Immunosuppressive CD10+ALPL+ Neutrophils Promote Resistance to Anti-PD-1 Therapy in HCC by Mediating Irreversible Exhaustion of T Cells

    Investigators analyzed the transcriptomic profiling at a single-cell resolution within tumor tissues from hepatocellular carcinoma patients scheduled to receive anti-PD-1-based immunotherapy.
    [Journal Of Hepatology]

    Full ArticleGraphical Abstract

    Acetate Acts as a Metabolic Immunomodulator by Bolstering T Cell Effector Function and Potentiating Antitumor Immunity in Breast Cancer

    The authors showed that acetate supplementation metabolically bolstered T cell effector functions and proliferation.
    [Nature Cancer]

    Abstract

    Metabolic Reprogramming via ACOD1 Depletion Enhances Function of Human Induced Pluripotent Stem Cell-Derived CAR-Macrophages in Solid Tumors

    Scientists found, via a pooled metabolic gene knockout CRISPR screen that KEAP1 and ACOD1 were strong regulators of the pro-inflammatory state in macrophages.
    [Nature Communications]

    Full Article

    Whole-Genome Screens Reveal Regulators of Differentiation State and Context-Dependent Migration in Human Neutrophils

    Researchers performed a comprehensive, genome-wide assessment of the molecular factors critical to proliferation, differentiation, and cell migration in a neutrophil-like cell line.
    [Nature Communications]

    Full Article

    NLGN4X TCR Transgenic T Cells to Treat Gliomas

    T cell receptor (TCR) discovery was performed using droplet-based single cell TCR sequencing of neuroligin 4 X-linked (NLGN4X)-tetramer-sorted T cells post vaccination.
    [Neuro-Oncology]

    Abstract

    TLR8 Escapes X Chromosome Inactivation in Human Monocytes and CD4+ T Cells

    Investigators conducted a comprehensive single-cell resolution analysis of the transcriptional regulation of both TLR7 and TLR8, in CD14+ monocytes and CD4+ T lymphocytes.
    [Biology of Sex Differences]

    Full Article

    Production of Therapeutic Levels of Human FIX-R338L by Engineered B Cells Using GMP-Compatible Medium

    Researchers established an advanced in vitro good manufacturing practice-compatible culturing system characterized by robust and consistent expansion rate, high viability, and efficient B cell differentiation.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractGraphical Abstract

    Large Extracellular Vesicles Derived from Human Regulatory Macrophages (L-EVMreg) Attenuate CD3/CD28-Induced T Cell Activation In Vitro

    Scientists investigated whether L-EVMreg also affected the CD3/CD28-mediated activation of T cells. Activation of human T cells was induced by CD3/CD28-coated beads in the absence or presence of Mreg or different concentrations of L-EVMreg .
    [Journal of Molecular Medicine]

    Full Article
    A person presenting slides at a scientific conference
    REVIEWS

    Dendritic Cells as Shepherds of T Cell Immunity in Cancer

    Investigators review the current understanding of dendritic cell T cell interactions at both priming and effector sites of immune responses.
    [Immunity]

    Abstract
    INDUSTRY AND POLICY NEWS

    Possible Misconduct Found in Papers from Italian Minister of Health

    An Italian newspaper has found duplicated images in eight cancer papers co-authored by the country’s minister of health, Orazio Schillaci. Dr. Schillaci published the papers between 2018 and 2022 while working in the faculty of medicine of the University of Rome Tor Vergata.
    [Science Insider]

    Editorial
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    JOB OPPORTUNITIES

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    Postdoctoral Fellow – Tumor Immunology

    National Cancer Institute – Bethesda, Maryland, United States

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