 | | Vol. 11.38 – 26 September, 2023 |
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| The authors showed that mitofusin-2 (MFN2) expression was positively correlated with the prognosis of multiple cancers. Genetic ablation of Mfn2 in CD8+ T cells dampened mitochondrial metabolism and function and promoted tumor progression.
[Science Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated that CXCR4hi neutrophils accumulated in the blood and inflamed skin in human psoriasis, and correlated with disease severity.
[Nature Communications] |
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| Researchers investigated how chimeric antigen receptor (CAR) T cell expansion dynamics and serum proteomics affect neutrophil recovery phenotypes after CD19-directed CAR T cell therapy.
[Science Advances] |
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| Scientists observed that programmed cell death protein 1 (PD-1)+ T cells demonstrated less activation and proliferation than activated PD-1– populations in vitro.
[JCI Insight] |
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| Investigators found that acute myeloid leukemia blast-released exosomes enhanced CD3 T cell apoptosis in both CD4 and CD8 T cells.
[Cell Communication and Signaling] |
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| The authors found that MAP4K1 was highly expressed in the glioma cells of human glioblastoma multiforme (GBM) specimens.They found that GBM cell-derived MAP4K1 impaired T cell migration and reduced CD8+ T cell infiltration.
[Life Science Alliance] |
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| Researchers investigated the impact of standard urban particulate matter (PM) and PM2.5 collected from Chiang Mai, Thailand, on human peripheral blood neutrophil functions.
[Scientific Reports] |
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| To analyze whether cytokines or immune cells could inhibit neutrophil extracellular trap (NET) formation, human granulocytes were incubated with IL-4, IL-10, transforming growth factor beta-2 or adenosine and then stimulated to release NETs.
[Scientific Reports] |
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| The downregulation of YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) promoted the expression of pro-inflammatory markers and improved the anti-cancer ability of immune cells in breast cancer.
[Experimental Cell Research] |
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| Investigators discuss the cellular and molecular cues that are important for memory T cell homeostasis and highlight opportunities for HIV to hijack normal immunological processes to establish long-term viral persistence.
[mBio] |
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| Scientists summarize our current knowledge of SHIP1 with a focus on innate immune cells, where they reflect on the most pertinent aspects described in the current literature.
[European Journal Of Immunology] |
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| APIX Therapeutics, Inc. announced that it has received clearance of its Investigational New Drug (IND) application from the US FDA to initiate a Phase I clinical trial for its first-in-class, immune tolerance restoration small molecule, LPX-TI641, for the treatment of multiple sclerosis.
[LAPIX Therapeutics, Inc.] |
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| Despite negative feedback from the research community, the US National Institutes of Health (NIH) has decided to move forward with a policy requiring that foreign scientists receiving ‘subawards’ from the agency must share their laboratory notebooks and other raw data with their research partner in the US.
[Nature News] |
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| November 28 – 30, 2023
San Francisco, California, United States |
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| | National Cancer Institute – Bethesda, Maryland, United States |
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| | Imperial College London – London, England, United Kingdom |
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| | McGill University – Montreal, Quebec, Canada |
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| | Chinese Academy of Sciences – Shanghai, China |
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| | University of Houston – Houston, Texas, United States |
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