 | | Vol. 11.39 – 3 October, 2023 |
| |
|
|
| The authors investigated neutrophils in tumor tissue of glioma and brain metastasis patients, with matched peripheral blood, and described the first in-depth analysis of neutrophil phenotypes and functions in these tissues.
[Cell] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists investigated whether disruption of the co-inhibitory receptors CTLA4 or PD-1 could restore CART function. CRISPR-Cas9-mediated deletion of CTLA4 in preclinical models of leukemia and myeloma improved CAR T cell proliferation and anti-tumor efficacy.
[Immunity] |
|
|
|
| Investigators identified a T cell receptor reactive to the recurrent D835Y driver mutation in the FMS-related receptor tyrosine kinase 3 tyrosine kinase domain (TCRFLT3D/Y). TCRFLT3D/Y-redirected T cells selectively eliminated primary human AML cells harboring the FLT3D835Y mutation in vitro and in vivo.
[Nature Cancer] |
|
|
|
| Researchers explored, using live single-cell imaging, the cytotoxic functions of γδ T cells upon interactions with tumor target cells with high temporal and spatial resolution.
[Nature Communications] |
|
|
|
| Scientists demonstrated that epitope-engineered HSPCs were shielded from CD123-targeted immunotherapy but remained functional, while CD123-deficient HSPCs displayed a competitive disadvantage.
[Journal Of Experimental Medicine] |
|
|
|
| Researchers found that CD8 tumor-infiltrating lymphocytes in both murine and human tumors exhibited overall similar phenotypic and transcriptional characteristics compared to corresponding subsets in the spleen of chronically infected mice.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
|
|
|
| By analyzing >1,000 publicly available antibody-antigen structures, investigators showed that many V-gene allelic polymorphisms in antibody paratopes were determinants for antibody binding activity.
[Cell Reports] |
|
|
|
| Different chemoattractants could drive qualitatively different modes of migration even though their receptors couple to the same Gαi family of G proteins. The authors used live-cell imaging to demonstrate that the responses differed in their signaling dynamics.
[Science Signaling] |
|
|
|
| Investigators demonstrated CD141+ dermal dendritic cells (DCs) and CD141hiVitD3 monocyte-derived DCs shared key immunological features including cell surface markers, reduced T cell stimulation, IL-10 production, and a common transcriptomic signature.
[iScience] |
|
|
|
|
| Scientists focus on the key obstacles pertaining to vaccine design and tumor environment that remain to be overcome in order to unleash the true potential of neoantigen vaccines in cancer therapy.
[Nature Reviews Immunology] |
|
|
|
| The authors discuss the developments for the therapeutic targeting of mTOR signaling with improved anticancer efficacy for the benefit of cancer patients in clinics.
[Signal Transduction And Targeted Therapy] |
|
|
|
|
| This year’s Nobel Prize in Physiology or Medicine has been awarded to biochemist Katalin Karikó and immunologist Drew Weissman for discoveries that enabled the development of mRNA vaccines against COVID-19.
[Nature News] |
|
|
|
| AbbVie has decided it can do without Caribou Biosciences. The Big Pharma is terminating its off-the-shelf CAR-T pact with the biotech, depriving Caribou of the chance to pocket up to $350 million in milestones per program.
[Fierce Biotech] |
|
|
|
|
| October 23 – 25, 2023
Toronto, Ontario, Canada |
|
|
|
|
|
| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
|
|
|
| | The University of British Columbia – Vancouver, British Columbia, Canada |
|
|
|
| | National Cancer Institute – Bethesda, Maryland, United States |
|
|
|
| | Imperial College London – London, England, United Kingdom |
|
|
|
| | McGill University – Montreal, Quebec, Canada |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
