Human Immunology News Volume 11.40 | Oct 10 2023

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    Laurisa Dohm
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    2023-10-10 | HIN 11.40


    Human Immunology News by STEMCELL Technologies
    Vol. 11.40 – 10 October, 2023
    TOP STORY

    Mitigation of Chromosome Loss in Clinical CRISPR-Cas9-Engineered T Cells

    To investigate whether Cas9-induced chromosome loss was a universal phenomenon and evaluate its clinical significance, the authors conducted a systematic analysis in primary human T cells.
    [Cell]

    Full ArticleGraphical AbstractPress Release
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    PUBLICATIONSRanked by the impact factor of the journal

    Human Endogenous Retroviruses As Epigenetic Therapeutic Targets in TP53-Mutated Diffuse Large B-Cell Lymphoma

    In TP53 mutation patients, multiple viral regulation pathways were repressed, resulting in the inhibition of immune modulation, as revealed by gene set enrichment analysis.
    [Signal Transduction And Targeted Therapy]

    Full Article

    SARS-CoV2 mRNA-Vaccination-Induced Immunological Memory in Human Non-Lymphoid and Lymphoid Tissues

    As opposed to lymphoid tissues, non-lymphoid organs harbored significantly elevated frequencies of Spike-specific CD4+ T cells compared to blood showing hallmarks of tissue residency and an expanded memory pool.
    [Journal Of Clinical Investigation]

    AbstractGraphical Abstract

    HIV-1 Treatment Timing Shapes the Human Intestinal Memory B-Cell Repertoire to Commensal Bacteria

    Researchers investigated how treatment timing affected intestinal memory B cell and plasmablast repertoires of HIV-1-infected humans.
    [Nature Communications]

    Full Article

    α-Ketoglutarate-Dependent KDM6 Histone Demethylases Regulate Interferon Stimulated Gene Expression in Lupus

    Monocytes from healthy volunteers and systemic lupus erythematosus patients at baseline or following interferon α treatment were analyzed by extracellular flux analysis, proteomics, metabolomics, chromatin immunoprecipitation and gene expression.
    [Arthritis & Rheumatology]

    AbstractGraphical Abstract

    Comprehensive Single-Cell Immune Profiling Defines the Patient Multiple Myeloma Microenvironment Following Oncolytic Virus Therapy in a Phase Ib Trial

    The authors conducted an investigator-initiated clinical trial to evaluate pelareorep in combination with dexamethasone and bortezomib, and defined the tumor immune microenvironment in multiple myeloma patients treated with this regimen.
    [Clinical Cancer Research]

    Abstract

    Apoptosis in Mesenchymal Stromal Cells Activates an Immunosuppressive Secretome That Correlates with Clinical Responses in Crohn’s Disease Patients

    Scientists analyzed the transcriptomes of mesenchymal stromal cells undergoing apoptosis and identified several immunomodulatory factors and chemokines dependent on caspase activation following Fas stimulation.
    [Molecular Therapy]

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    Upregulation of Exosome Secretion from Tumor-Associated Macrophages Plays a Key Role in the Suppression of Anti-Tumor Immunity

    Analysis of patient melanoma tissues indicated that tumor-associated macrophages exosomes contributed significantly to CD8+ T cell suppression.
    [Cell Reports]

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    The Ligand-Dependent Suppression of TCR Signaling by the Immune Checkpoint Receptor LAG3 Depends on the Cytoplasmic RRFSALE Motif

    Lymphocyte activation gene 3 (LAG3) is an inhibitory immune checkpoint receptor that restrains autoimmune and antitumor responses, but its evolutionarily conserved cytoplasmic tail lacks classical inhibitory motifs. Scientists used a fluorescent human T cell reporter system to study the function of LAG3.
    [Science Signaling]

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    REVIEWS

    The Effect of Physical Exercise on Anticancer Immunity

    The authors address the importance of muscular activity for maintaining a healthy immune system and discuss the effects of a single bout of exercise, and those of ‘regular’ exercise on anticancer immunity, including tumor infiltrates.
    [Nature Reviews Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Extending Efficacy for CAR T-Cell Therapies

    Dr. Shivani Srivastava received a NCI MERIT Award to investigate how to improve engineered cancer immunotherapies against solid tumors through reservoirs of self-renewing immune cells.
    [Fred Hutch Cancer Center]

    Editorial
    FEATURED EVENT

    Cell Symposia: Structural Biology from the Nanoscale to Cellular Mesoscale

    November 3 – 5, 2023
    Huangshan, China

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    JOB OPPORTUNITIES

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    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Fellow – Airway Inflammation

    Institut Necker Enfants-Malades – Paris, France

    Faculty Positions – Cell Therapies

    The University of British Columbia – Vancouver, British Columbia, Canada

    Scientific Director – Intramural Research Program

    National Cancer Institute – Bethesda, Maryland, United States

    Research Associate – Tissue Immunology

    Imperial College London – London, England, United Kingdom

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