 | | Vol. 11.43 – 31 October, 2023 |
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| Mechanistically, E-selectin engagement triggered Bruton’s tyrosine kinase-dependent tyrosine phosphorylation of NLRP3.
[Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers used bulk and single-cell transcriptomics to analyze expression of transposable elements in subpopulations of mouse and human CD8+ tumor-infiltrating T lymphocytes.
[Science Immunology] |
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| Investigators conducted large-scale and cohort-wide immunophenotyping of 46 peripheral immune cells using Human Immunology Protocol of comprehensive eight-color flow cytometric analyses.
[Annals Of The Rheumatic Diseases] |
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| A first-in-human, Phase I study of adjuvant PRGN-2012 treatment in adult patients with severe, aggressive recurrent respiratory papillomatosis demonstrated the overall safety and clinically meaningful benefit observed with PRGN-2012, with a 50% complete response rate in patients treated at the highest dose.
[Science Translational Medicine] |
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| The comprehensive immune cell dysregulation in total 263 clinical peripheral blood samples composed of active systemic lupus erythematosus (SLE), remission SLE, and healthy controls was investigated via mass cytometry, flow cytometry, and single-cell RNA sequencing.
[Advanced Science] |
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| The authors detail findings from the first in-human clinical trial evaluated a single dose of BLB201, a PIV5-vectored respiratory syncytial virus (RSV) vaccine administrated via intranasal route, for safety and immunogenicity in RSV-seropositive healthy adults.
[Science Advances] |
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| Scientists demonstrated that IL-12α and EBI3 were stable proteins in isolation that acted as anti-inflammatory molecules. Both reduced secretion of proinflammatory cytokines and induced the development of regulatory T cells.
[Science Advances] |
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| Researchers found that phosphatidylinositol 4,5-bisphosphate was enriched in the nuclei of human TH17 cells, which depended on the kinase PIP5K1α, and that inhibition of PIP5K1α impaired IL-17A production.
[Science Signaling] |
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| Expansion of human Tregs in the presence of porcine PBMC allowed the selection of a distinct Treg subset, co-expressing the activation/memory surface markers HLA-DR and CD27 with enhanced proportion of FOXP3+Helios+ Tregs.
[JCI Insight] |
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| The authors discuss the unique complexities associated with the clinical development of these therapeutics, such as HLA restriction, T cell receptor retrieval, potency assessment, and the potential for cross-reactivity.
[Nature Reviews Drug Discovery] |
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| The group behind Plan S has already accelerated the open-access movement. Now it is proposing a more radical revolution for science publishing.
[Nature News] |
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| November 28 – 30, 2023
Philadelphia, Pennsylvania, United States |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | University of Notre Dame – Notre Dame, Indiana, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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