 | | Vol. 11.44 – 7 November, 2023 |
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| Investigators uncovered an inflammatory loop between tumor cells and interleukin-1β-expressing tumor-associated macrophages, a subset of macrophages elicited by a local synergy between prostaglandin E2, and tumor necrosis factor.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Anti-NMDA receptor (NMDAR)-specific chimeric autoantibody receptor T cells recognized a large panel of human patient-derived autoantibodies, released effector molecules, proliferated, and selectively killed antigen-specific target cell lines even in the presence of high autoantibody concentrations.
[Cell] |
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| Scientists systematically engineered new CD3 chimeric antigen receptors (CARs), each containing only one of the CD3 intracellular domains. CARs containing CD3δ, CD3ε, or CD3γ cytoplasmic tails outperformed the conventional ζ CAR T cells in vivo.
[Nature Immunology] |
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| Researchers described that pluripotent stem cell-derived human colonic organoids co-developped a diverse population of immune cells, including those that undergo stereotypical steps in differentiation, resulting in the generation of functional macrophages.
[Cell Stem Cell] |
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| The authors developed a new approach that provided large quantities of Tregs with high purity and excellent features, sourced from thymic tissue routinely removed during pediatric cardiac surgeries (thyTregs).
[Journal Of Experimental Medicine] |
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| Investigators showed that mice with β cell ornithine decarboxylase (ODC) deletion were protected against toxin-induced diabetes, suggesting a cell-autonomous role of ODC during β cell stress.
[Cell Reports Medicine] |
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| Scientists performed spatial transcriptomic analysis of head and neck squamous cell carcinoma (HNSCC) specimens with differing immune infiltration and single-cell RNA sequencing of five pairs of tumor and adjacent tissues.
[Cancer Research] |
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| Researchers successfully engineered CD4+ T cells into Foxp3-T cells that transiently exhibited an immunosuppressive phenotype and functionally suppressed the proliferation of effector T cells
[Nano Letters] |
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| Scientists found that MΦ-C4 exhibited relatively low expression of both M1 and M2 signature genes, loss of inflammatory pathways, and antigen presentation, instead demonstrating enhanced signaling for proliferation, mitochondrial functions, and metabolism.
[Experimental & Molecular Medicine] |
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| The authors synthesize the evidence showing that the microbiota is an important determinant of both cancer treatment efficacy and treatment-induced acute and long-term toxicity, and discuss the complex and inter-related mechanisms involved.
[Nature Reviews Immunology] |
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| Investigators focus on the mechanisms underlying the mitochondrial DNA-triggered activation of the cGAS-MITA/STING pathway.
[Cellular & Molecular Immunology] |
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| Kyverna Therapeutics announced the signing of a multi-year research funding agreement with Charité – Universitätsmedizin Berlin to investigate the impact of B- and plasma cell-targeting therapies on the immunologic profile and clinical outcomes of patients with systemic autoimmune diseases.
[Kyverna Therapeutics] |
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| November 16 – 18, 2023
Boston, Massachusetts, United States |
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| | Emory University Lowance Center for Human Immunology – Atlanta, Georgia, United States |
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| | Seattle Children’s Research Institute – Seattle, Washington, United States |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Notre Dame – Notre Dame, Indiana, United States |
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