Human Immunology News Volume 11.46 | Nov 21 2023

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    Noshin Noorjahan
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    2023-11-21 | HIN 11.46


    Human Immunology News by STEMCELL Technologies
    Vol. 11.46 – 21 November, 2023
    TOP STORY

    Targeting of Intracellular Oncoproteins with Peptide-Centric CARs

    Scientists showed that the neuroblastoma immunopeptidome was enriched with peptides derived from proteins essential for tumorigenesis.
    [Nature]

    Full Article
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    Single Cell Dynamics of Tumor Specificity vs Bystander Activity in CD8+ T Cells Define the Diverse Immune Landscapes in Colorectal Cancer

    The authors pursued a deep single cell mapping of colorectal cancer CD8+ T cells on transcriptomic and T cell receptor repertoire levels in a diverse patient cohort, with additional surface proteome validation.
    [Cell Discovery]

    Full Article

    Enhanced SARS-CoV-2 Humoral Immunity Following Breakthrough Infection Builds upon the Preexisting Memory B Cell Pool

    To investigate how B cells respond to repeated SARS-CoV-2 antigen exposure by Wu01 booster vaccination and Omicron breakthrough infection, scientists performed a molecular longitudinal analysis of the memory B cell pool.
    [Science Immunology]

    Abstract

    Epigenetic Profiles Guide Improved CRISPR/Cas9-Mediated Gene Knockout in Human T Cells

    Researchers explored a strategy to select optimal guide RNAs using their pooled data on CRISPR/Cas9-mediated gene knockout in human T cells.
    [Nucleic Acids Research]

    Full Article
    Graphical Abstract

    Single Cell Transcriptomics Shows That Malaria Promotes Unique Regulatory Responses across Multiple Immune Cell Subsets

    Investigators analyzed the immune landscape with single cell RNA sequencing during P. falciparum malaria.
    [Nature Communications]

    Full Article

    Inflammatory Macrophages Reprogram to Immunosuppression by Reducing Mitochondrial Translation

    Using mice lacking Zeb1 in their myeloid cells and human patient samples, researchers showed that ZEB1 played a dual role, being essential in both initiating and resolving inflammation by inducing macrophages to transition into an immunosuppressed state.
    [Nature Communications]

    Full Article

    A Partial Human LCK Defect Causes a T Cell Immunodeficiency with Intestinal Inflammation

    Scientists demonstrated in mouse models that completed versus partial loss-of-function lymphocyte-specific protein tyrosine kinase (LCK) caused disease with differing phenotypes.
    [Journal of Experimental Medicine]

    Full Article
    Graphical Abstract

    scCURE Identifies Cell Types Responding to Immunotherapy and Enables Outcome Prediction

    Based on Gaussian mixture modeling, Kullback-Leibler divergence, and mutual nearest-neighbors criteria, scRNA-seq data-based Changed and Unchanged cell Recognition during immunotherapy (scCURE) could faithfully discriminate between cells affected or unaffected by immunotherapy intervention.
    [Cell Reports Methods]

    Full ArticleGraphical Abstract

    IGH Repertoire Analysis at Scale: Deciphering the Complexity of B Cell Infiltration and Migration in Esophageal Squamous Cell Carcinoma

    Investigators examined the immunoglobulin heavy chain (IGH) repertoires in 496 multi-regional tumors, 107 normal tissue, and 48 metastatic lymph node samples obtained from 107 patients with esophageal squamous cell carcinoma.
    [Cancer Gene Therapy]

    Abstract
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    REVIEWS

    New Sights of Low Dose IL-2: Restoration of Immune Homeostasis for Viral Infection

    The authors summarize the role of IL-2 or IL-2 complexes in viral infections as well as the application of ld-IL-2 in the context of autoimmune diseases combined with viral infections.
    [Immunology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Icahn School of Medicine at Mount Sinai Secures $5 Million NIH Grant for Cutting-Edge Cancer Target Discovery and Development Center

    The Department of Immunology and Immunotherapy and the Icahn Genomics Institute at the Icahn School of Medicine at Mount Sinai have been awarded a $5 million grant to establish a state-of-the-art center dedicated to the discovery and development of cutting-edge targets for cancer therapy.
    [Icahn School of Medicine]

    Press Release
    FEATURED EVENT

    Advances in Cancer Immunotherapy™: A Focus on Gastrointestinal Cancers

    December 4, 2023
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Officer – Translational Immunology

    University of Melbourne – Melbourne, Australia

    Postdoctoral Fellowships – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    Scientific Research Personnel – Immunology, Vaccinology & Nanomedicine

    Chinese Academy of Sciences – Shenzhen, China

    Postdoctoral Researcher – Cancer Bioinformatics and Immunotherapies

    Armenian Bioinformatics Institute – Yerevan, Armenia

    Research Associate – Immunophenotyping of Tumor Microenvironment

    Cedars-Sinai – Los Angeles, California, United States

    > See All Jobs

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