Human Immunology News Volume 11.47 | Nov 28 2023

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    Noshin Noorjahan
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    2023-11-28 | HIN 11.47


    Human Immunology News by STEMCELL Technologies
    Vol. 11.47 – 28 November, 2023
    TOP STORY

    Structural Insights into Cytokine Cleavage by Inflammatory Caspase-4

    Investigators demonstrated that the lipopolysaccharide receptor caspase-4 from humans and other mammalian species could cleave pro-IL-18 with an efficiency similar to pro-IL-1β and pro-IL-18 cleavage by the prototypical IL-1-converting enzyme caspase-1.
    [Nature]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Autoimmune Amelogenesis Imperfecta in Patients with APS-1 and Celiac Disease

    Scientists showed that the vast majority of patients with autoimmune polyglandular syndrome type-1 (APS-1) and celiac disease develop autoantibodies against ameloblast-specific proteins, the expression of which was induced by AIRE in the thymus.
    [Nature]

    AbstractPress Release

    Early-to-Mid Stage Idiopathic Parkinson’s Disease Shows Enhanced Cytotoxicity and Differentiation in CD8 T Cells in Females

    Single-cell RNA-sequencing analysis showed the accelerated differentiation within CD8 compartments enhanced cytotoxic pathways in CD8 terminally-differentiated effector memory and effector memory cells, while CD8 central memory and naïve cells were already more-active and transcriptionally-reprogrammed.
    [Nature Communications]

    Full Article

    Multifaceted Immune Dysregulation Characterizes Individuals At-Risk for Rheumatoid Arthritis

    Researchers presented a cross-sectional comparative analysis among three groups that included antibodies to citrullinated protein antigens (ACPA) positive individuals without inflammatory arthritis, ACPA negative individuals, and individuals with early, ACPA positive clinical rheumatoid arthritis.
    [Nature Communications]

    Full Article

    GRP78-CAR T Cell Effector Function against Solid and Brain Tumors Is Controlled by GRP78 Expression on T Cells

    The authors showed that glucose-regulated protein 78 (GRP78) was highly expressed on the cell surface of multiple solid and brain tumors, making cell surface GRP78 a promising chimeric antigen receptor (CAR) T cell target.
    [Cell Reports Medicine]

    Full ArticlePress ReleaseGraphical Abstract

    AIM/CD5L Ameliorates Autoimmune Arthritis by Promoting Removal of Inflammatory DAMPs at the Lesions

    Investigators showed that apoptosis inhibitor of macrophage (AIM) protein regulated arthritis by promoting removal of lesional danger-associated molecular patterns (DAMPs) both physiologically and therapeutically.
    [Journal of Autoimmunity]

    Full Article

    PRMT1 Inhibition Activates the Interferon Pathway to Potentiate Antitumor Immunity and Enhance Checkpoint Blockade Efficacy in Melanoma

    Researchers found that protein arginine methyl transferase 1 (PRMT1) expression was inversely correlated with the number and activity of CD8+ T cells within melanoma specimens.
    [Cancer Research]

    Abstract

    Circulating T Follicular Helper 2 Cells, T Follicular Regulatory Cells, and Regulatory B Cells Are Effective Biomarkers for Predicting the Response to House Dust Mite Sublingual Immunotherapy in Patients with Allergic Respiratory Diseases

    Scientists performed house dust mite sublingual immunotherapy for 20 patients with atopic asthma comorbid with allergic rhinitis who were already receiving ordinary treatments including inhaled corticosteroid.
    [Frontiers in Immunology]

    Full Article

    CD8+ Treg Cells Play a Role in the Obesity-Associated Insulin Resistance

    Investigators characterized the CD8+ Treg cells in human peripheral blood and adipose tissue, specifically, to address the effect of obesity and insulin resistance in this regulatory immune cell population.
    [Life Sciences]

    Abstract
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    REVIEWS

    γδ T Cells: Origin and Fate, Subsets, Diseases, and Immunotherapy

    The authors elucidate functional differences between γδ T cells and their αβ T cell counterparts and provide an overview of major milestones in γδ T cell research since their discovery in 1984.
    [Signal Transduction and Targeted Therapy]

    Full Article

    The Immunometabolic Ecosystem in Cancer

    Scientists examine the metabolic interplay between tumor-resident cells and how targeted inhibition of specific metabolic enzymes in malignant cells could elicit pro-tumorigenic effects in non-transformed tumor-resident cells and inhibit the function of tumor-specific T cells.
    [Nature Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    IVI, KAIST to Collaborate in Global Vaccine Research to Accelerate Innovations in Vaccines and Immunology

    The International Vaccine Institute (IVI) and the Korea Advanced Institute of Science and Technology (KAIST) signed a memorandum of understanding for global vaccine research collaboration.
    [International Vaccine Institute]

    Press Release

    University of Bonn Receives Three ERC Consolidator Grants

    Another big success for the University of Bonn in securing grants from the European Research Council (ERC), with three researchers receiving an ERC Consolidator Grant: Drs. Jan Hasenauer, Florian I. Schmidt, and Evgeny Shinder.
    [University of Bonn]

    Press Release
    FEATURED EVENT

    ESMO Immuno-Oncology Congress 2023

    December 6 – 8, 2023
    Geneva, Switzerland

    > See All Events

    JOB OPPORTUNITIES

    Faculty Positions – Medicine

    Westlake University – Zhejiang, China

    Postdoctoral Fellow – CAR T Cell Cancer Therapy

    Oslo University Hospital – Oslo, Norway

    Postdoctoral Research Scientist – Immunity and Inflammation

    Rutgers Health – Newark, New Jersey, United States

    Research Officer – Translational Immunology

    University of Melbourne – Melbourne, Australia

    Postdoctoral Fellowships – Cancer Research

    NIH National Cancer Institute – Bethesda, Maryland, United States

    > See All Jobs

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