 | | Vol. 11.48 – 5 December, 2023 |
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| To identify noncoding regions with accessible chromatin that associate with cell-state-defining gene expression patterns, researchers leveraged multimodal single-nucleus RNA and assay for transposase-accessible chromatin sequencing data across 28,674 cells from the inflamed synovial tissue of 12 donors.
[Nature Genetics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors tried to enhance the local innate immune response in relapsed high-grade glioma by intracranially injecting poly(I:C) to establish a robust antitumor immune response in this registered clinical trial.
[Cellular & Molecular Immunology] |
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| Scientists showed that mitochondrial CPT1A downregulation following viral infection restrained, while its induction by epigenetic perturbations sustained, a double-stranded RNA-activated IFN-I response.
[Molecular Cell] |
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| Investigators conducted a single-cell multi-omics analysis of transcriptional, clonal, and phenotypic profiles from pre- to one-month post-infusion of CAR+ and CAR− T cells from patients from a CARTELL study who received a donor-derived 4-1BB CAR product targeting CD19.
[Nature Communications] |
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| To study and then harness the tumor-specific T cell dynamics after allogeneic hematopoietic stem cell transplant, scientists typed the frequency, phenotype, and function of lymphocytes directed against tumor-associated antigens in 39 consecutive transplanted patients, for 1 year after transplant.
[Science Advances] |
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| Researchers demonstrated that EpCAM–CAR-T cells costimulated by Dectin-1 exhibited robust antitumor activity without adverse effects in xenograft mouse models and EpCAM-humanized mice.
[Science Advances] |
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| Scientists analyzed peripheral blood mononuclear cells from patients with multiple myeloma during and after SARS-CoV-2 vaccination and breakthrough infection.
[Leukemia] |
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| The authors found that granzyme A- and B-producing Th2 cells played a key role in the promotion of pathogenic Th2 cells via protease-activated receptor (Par)-1 and induced the phosphorylation of p38 mitogen-activated protein kinase.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers characterized the IL-33-driven transcriptomic changes in cultured primary bronchial epithelial cells from patients with asthma and healthy controls.
[American Journal Of Physiology-Lung Cellular And Molecular Physiology] |
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| Scientists discuss the design of nanovaccines, including lipid-nanocarrier-based messenger RNA nanovaccines, highlighting engineering strategies for different administration routes, including nasal administration.
[Nature Reviews Bioengineering] |
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| Dr Matt Hepworth has been awarded a £2.8 million, 8-year Career Development Award from the Wellcome Trust to conduct groundbreaking research into group 3 innate lymphoid cell and their role in maintaining both intestinal and whole-body health.
[The University of Manchester] |
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| January 16 – 19, 2024
San Diego, California, United States & Virtual |
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| | Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany |
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| | Institut Necker Enfants Malades – Paris, France |
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| | Institut Pasteur – Paris, France |
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| | Westlake University – Zhejiang, China |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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