Human Immunology News Volume 12.00 | Jan 9 2024

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    2024-01-09 | HIN 12.00


    Human Immunology News by STEMCELL Technologies
    Vol. 12.00 – 9 January, 2024
    TOP STORY

    A TCF4-Dependent Gene Regulatory Network Confers Resistance to Immunotherapy in Melanoma

    Using single-cell, spatial multi-omics, the authors showed that the tumor microenvironment promoted the emergence of a complex melanoma transcriptomic landscape.
    [Cell]

    Full ArticlePress ReleaseGraphical Abstract
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    Integrative Analysis of Neuroblastoma by Single-Cell RNA Sequencing Identifies the NECTIN2-TIGIT Axis as a Target for Immunotherapy

    Researchers dissected the immunoregulatory interactions in neuroblastoma by single-cell RNA-sequencing of 24 tumors to identify strategies for optimizing immunotherapy efficacy.
    [Cancer Cell]

    Full ArticleGraphical Abstract

    Immune Evasion of Dormant Disseminated Tumor Cells Is Due to Their Scarcity and Can Be Overcome by T Cell Immunotherapies

    Investigators found that the source of recurrence—disseminated tumor cells— evaded endogenous immunity directed against tumor neoantigens.
    [Cancer Cell]

    AbstractGraphical Abstract

    IKAROS and AIOLOS Directly Regulate AP-1 Transcriptional Complexes and Are Essential for NK Cell Development

    Using conditional genetic inactivation, the authors showed that Ikzf1/Ikaros was essential for normal natural killer cell lymphopoiesis and IKZF1 directly repressed Cish, a negative regulator of IL-15 receptor resulting in impaired IL-15 receptor signaling.
    [Nature Immunology]

    Abstract

    PD-1 Defines a Distinct, Functional, Tissue-Adapted State in Vδ1+ T Cells with Implications for Cancer Immunotherapy

    Scientists demonstrated that intratumoral TRDV1 transcripts predicted anti-programmed cell death protein 1 (PD-1) checkpoint inhibition response in patients with melanoma, particularly those harboring below average neoantigens.
    [Nature Cancer]

    Full Article

    Eomes-Dependent Mitochondrial Regulation Promotes Survival of Pathogenic CD4+ T Cells during Inflammation

    Researchers revealed that the impact of Eomes on effector CD4+ T cell longevity was associated with sustained expression of multiple genes involved in mitochondrial organization and functions.
    [Journal Of Experimental Medicine]

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    Graphical
    Abstract

    Characterizing Immune Variation and Diagnostic Indicators of Preeclampsia by Single-Cell RNA Sequencing and Machine Learning

    The authors utilized single-cell RNA sequencing to dissect the involvement of circulating immune cells in preeclampsia. They revealed downregulation of immune response in lymphocyte subsets in preeclampsia.
    [Communications Biology]

    Full Article

    YTHDF2-Mediated circYAP1 Drives Immune Escape and Cancer Progression through Activating YAP1/TCF4-PD-L1 Axis

    Investigators discovered that higher expression of circYAP1 was associated with a worse prognosis of colorectal cancer patients. Functional experiments in vitro and in vivo showed that circYAP1 upregulation inhibited the cytotoxicity of CD8+ T cells cytotoxicity by upregulating PD-L1.
    [iScience]

    AbstractGraphical Abstract

    Immune, Metabolic Landscapes of Prognostic Signatures for Lung Adenocarcinoma Based on a Novel Deep Learning Framework

    A prognostic risk model for lung adenocarcinoma was constructed by the biomarkers HLA-DRB1, SCGB1A1, and HLA-DRB5 screened by Cox regression analysis, dividing the patients into high-risk and low-risk groups.
    [Scientific Reports]

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    REVIEWS

    The Pathophysiology of Sepsis and Precision-Medicine-Based Immunotherapy

    Immunotherapy trials for sepsis, mainly aimed at suppressing the immune response have largely failed, in part owing to unresolved patient heterogeneity in the underlying immune disbalance. The past decade has brought the promise to break this blockade through technological developments.
    [Nature Immunology]

    Abstract

    Nanotechnology Applications in Breast Cancer Immunotherapy

    Scientists highlight the recent advances in nanoimmunotherapeutic development, with a focus on breast cancer.
    [Small]

    Abstract
    INDUSTRY AND POLICY NEWS

    Fehniger Receives Grant for Trial of Immunotherapy against Melanoma

    Dr. Todd Fehniger and colleagues have received $1.5 million from the Rising Tide Foundation for Cancer Research and the Melanoma Research Alliance.
    [Washington University in St.Louis]

    Press Release
    FEATURED EVENT

    The 62nd Midwinter Conference of Immunologists

    January 27 – 30, 2024
    Pacific Grove, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Principal Investigators – Human Cell Lineage Atlas Facility

    Guangzhou Institutes of Biomedicine and Health – Guangzhou, China

    Postdoctoral Fellows – Immunology

    Northwestern University – Chicago, Illinois, United States

    Postdoctoral Position – Gene Regulation of Cell & Metabolic Plasticity

    IDIBAPS – Barcelona, Spain

    PhD Positions – Tissue Regeneration and Cancer Immunotherapy

    Albert-Ludwigs-University Freiburg – Freiburg im Breisgau, Germany

    Postdoctoral Position – Inflammation/Regeneration

    Institut Pasteur – Paris, France

    > See All Jobs

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