 | | Vol. 12.02 – 16 January, 2024 |
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| The authors showed that cell surface marker recognition by antibody fragments displayed on membrane-derived particles encapsulating CRISPR–Cas9 protein and guide RNA could deliver genome editing tools to specific cells.
[Nature Biotechnology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators described a reliable platform capable of up to 2,000-fold expansion of human type 2 innate lymphoid cells (ILC2s) within four weeks, whose molecular and cellular ILC2 profiles were validated by single-cell RNA sequencing.
[Cell] |
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| NK cell activation on NKp44/HLA-DP interactions was assessed in vitro using plate-bound HLA-DP molecules and HLA-DPB wildtype versus knock-out human cholangiocyte organoids.
[Gut] |
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| Scientists developed a technique to restrict genetic recombination to regulatory T cells (Tregs) only in skin. Selective depletion of skin Tregs resulted in T cell–mediated inflammation of hair follicles
[Science Immunology] |
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| Magnetic nanoparticles conjugated with anti-CD3 mAb (Ab-MNPs) were characterized using transmission and scanning electron microscopy, and their distribution was assessed using a nanoparticle tracking analyzer.
[Advanced Science] |
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| Piezoelectric catalysis was utilized to reduce intracellular NAD+ to NADH for local tumor cell senescence for the first time.
[Small] |
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| Scientists tested the hypothesis that type-2 inflammation indicated by elevated blood eosinophils and fraction of exhaled nitric oxide would be associated with accelerated lung function decline in the general population.
[Thorax] |
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| The testicular germ cell tumor transcriptome data in The Cancer Genome Atlas Program database was used to perform consensus clustering analysis to construct a prognostic model for testicular germ cell tumors.
[Heliyon] |
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| Researchers found that the key factors of glutamine metabolism, glutaminase 1 (GLS) and mitochondrial aspartate transaminase (GOT2), showed opposite expression patterns in breast cancer samples.
[Heliyon] |
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| Scientists highlight advances in each antibody–drug conjugate component — the monoclonal antibody, payload, linker and conjugation chemistry — and provide detailed discussions on selected examples of emerging novel antibody–drug conjugates of each format.
[Nature Reviews Clinical Oncology] |
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| The authors focus on the members of this receptor family expressed on immune cells and how they govern immune and neuro-immune pathways underlying various physiological and pathological states.
[Immunity] |
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| Until now, Tecentriq has been given directly into patients’ veins by IV infusion which takes approximately 30-60 minutes. The new subcutaneous injection will cut treatment time to approximately seven minutes, with most injections taking between four and eight minutes.
[Roche] |
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| February 11 – 16, 2023
Barga, Italy |
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| | Karolinska Institutet – Solna, Sweden |
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| | Sanofi – Cambridge, Massachusetts, United States |
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| | Roche – Penzberg, Germany |
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| | Guangzhou Institutes of Biomedicine and Health – Guangzhou, China |
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| | Northwestern University – Chicago, Illinois, United States |
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