 | | Vol. 12.02 – 23 January, 2024 |
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| Investigators evaluated the impact of CPX-351 and “7+3” combination on mucosal barrier function, gut microbial composition and function, and antifungal colonization resistance in preclinical models of intestinal damage in vitro and in vivo and fecal microbiota transplantation.
[Gut] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Modeling initial T-dependent B cell activation with CD40L en vitro, researchers showed that FAS competent cells with transient FAS ligation showed specifically decreased mTOR axis activation without apoptosis.
[Science Immunology] |
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| By locating potential interaction axes between trophoblast and uterine NK (uNK) cells using single-cell transcriptomics and in vitro modeling of these interactions in organoids, investigators identified a uNK cell-derived cytokine signal that promoted trophoblast differentiation.
[Cell Stem Cell] |
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| Scientists performed an in-depth survey of the single-cell transcriptomes and clonal relationship of intra-tumoral T cells from children with brain tumors.
[Nature Cancer] |
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| Researchers analyzed liver tissue from two independent patient cohorts with acute liver failure and identified hepatic T cell infiltration as a prominent feature in human acute liver failure.
[Hepatology] |
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| Scientists developed an antibody (15B6) that bound next to the membrane at the protease-sensitive region, did not bind to shed mesothelin, and made CAR-T cells that had much higher anti-tumor activity than a CAR-T that bound to shed mesothelin.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors conducted a meta-analysis on the predictive value of neutrophil-lymphocyte ratio in immune checkpoint blockade response and investigated tumor-associated neutrophils’ role in urothelial bladder carcinoma.
[British Journal Of Cancer] |
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| Investigators retrospectively analyzed 26 consecutive patients with non-malignant disorders grafted using alemtuzumab serotherapy and capping of graft T cells to a maximum of 600 million/kg.
[Scientific Reports] |
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| Researchers established a protocol for ex vivo expansion of Vγ9Vδ2 T cells from healthy donors’ peripheral blood mononuclear cells by culture with zoledronate and addition of IL-2, and IL-15 or IL-18 or neither.
[Scientific Reports] |
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| Investigators provide an overview of the recent progress in the development of synthetic nanomaterials to deliver plasmid DNA or mRNA for in situ reprogramming of T cells and macrophages, focusing especially on in situ CAR therapies.
[Advanced Materials] |
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| In the face of the current situation of poor therapeutic effects of tumor immunotherapy, combined application of targeted immune cell fatty acid metabolism seems to have good therapeutic potential, which is blocked at immune checkpoints.
[Cell Death Discovery] |
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| Calypso Biotech announced that it has entered into an agreement to be acquired by Novartis. Calypso is focused on the research and development of monoclonal antibodies for an array of autoimmune indications, with an expertise in IL-15 biology.
[Calypso Biotech] |
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| The US health regulator on asked a host of drugmakers, including Gilead Sciences, Johnson & Johnson, and Novartis to add a serious warning on the label of their cancer therapies that use CAR-T technology.
[Reuters] |
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| February 14 – 18, 2024
Cancun, Mexico |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | Roche – Penzberg, Germany |
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| | Guangzhou Institutes of Biomedicine and Health – Guangzhou, China |
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| | Northwestern University – Chicago, Illinois, United States |
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