 | | Vol. 12.03 – 30 January, 2024 |
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| Using a multiomics approach including multidimensional flow cytometry, transcriptomic, proteomic, metabolomic, and metagenomic datasets, the authors assessed the impact of each diet, and dietary switch, on host immunity and the microbiota.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers employed a clonality-supervised deep learning methodology to dissect key pathological features implicated in mycosis fungoides, the most common cutaneous T-cell lymphoma.
[Nature Communications] |
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| Investigators characterized the mechanism of CD8+ T cell invasion into biliary epithelial cells (BECs). CD8+ T cells observed within BEC were large, eccentric, and expressed E-cadherin, CD103, and CD69.
[Nature Communications] |
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| The authors found that myeloid effectors interacting with tumor-targeting antibody-opsonized lung cancer cells employed antibody-dependent trogocytosis but not antibody-dependent phagocytosis.
[Cancer Research] |
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| Researchers included four independent cohorts, including 234 patients who underwent partial or radical nephrectomy at Zhongshan Hospital, and 117 metastatic patients who were treated with immune checkpoint inhibitor or tyrosine kinase inhibitor alone.
[Journal For Immunotherapy Of Cancer] |
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| B and T cell responses were evaluated in patients with rheumatoid arthritis or psoriatic arthritis after one or two weeks of methotrexate (MTX) withdrawal following each COVID-19 vaccine dose and compared with those who maintained MTX.
[npj Vaccines] |
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| Investigators analyzed the immune environment of primary and lung metastases in 38 patients with soft tissue sarcoma using immunohistochemistry.
[British Journal of Cancer] |
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| Researchers retrieved eRNA expression profiles from TCGA database and identified immune-related eRNAs by assessing their co-expression with immune genes.
[Aging-Us] |
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| To explore the mechanism underlying the action of anti-OX40 agonists to improve the anti-tumor efficacy, scientists analyzed the dynamic changes of tumor-infiltrating immune cells at different days post-treatments using single-cell RNA-sequencing.
[Biochemical and Biophysical Research Communications] |
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| Agents designed to engage the antitumour activities of other immune cells, including natural killer cells and myeloid cells, are showing promise and have the potential to treat a broader range of cancers.
[Nature Reviews Immunology] |
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| The authors discuss biomarkers for immunotherapy in renal cell carcinoma (RCC), highlighting current practices and emerging innovations, aiming to contribute to improved outcomes for patients with RCC.
[Immunotherapy] |
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| Sanofi is paying $40 million to add another cytokine—IL-10—to its hit list. This has secured Sanofi the chance to work with Synthekine to overcome long-standing barriers to the use of the cytokine in the treatment of inflammatory diseases.
[Fierce Biotech] |
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| February 14 – 16, 2024
Hinxton, England, United Kingdom |
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| | University of Minnesota – Minneapolis, Minnesota, United States |
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| | Cellistic – Mont-Saint-Guibert, Belgium |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | Guangzhou Institutes of Biomedicine and Health – Guangzhou, China |
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