 | | Vol. 12.04 – 6 February, 2024 |
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| Investigators studied a unique prospective cohort of vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) patients. They showed that monocytes from VEXAS were quantitatively and qualitatively impaired and displayed features of exhaustion with aberrant expression of chemokine receptors.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Patients received guadecitabine with durvalumab. The study enrolled 57 patients, six in Phase Ib with safety being the primary objective and 51 in Phase II, comprising 2 cohorts.
[Nature Communications] |
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| The authors performed a comprehensive immunological characterization of SPG11–hereditary spastic paraplegia, including examination of three human postmortem brain donations, immunophenotyping of patients’ peripheral blood cells and patient-specific induced pluripotent stem cell-derived microglia-like cells.
[Acta Neuropathologica] |
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| Scientists identified a novel immunotherapeutic target, immunoglobulin superfamily member 1 (IGSF1), by proteome analysis, a membrane glycoprotein proposed to regulate thyroid function.
[Cancer Immunology Research] |
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| Single-cell mass cytometry was utilized to analyze immune cell subsets in peripheral blood mononuclear cells obtained from non-small cell lung cancer patients before and 12 weeks after single-agent immunotherapy.
[npj Precision Oncology] |
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| The authors generated pre-clinical investigations of autologous anti-GD2 CAR T cells tested against 2D and 3D models of glioblastoma primary cells.
[npj Precision Oncology] |
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| Researchers showed that the RNA-editing enzyme ADAR1 was a crucial stemness factor that promoted leukemia-initiating cell self-renewal by attenuating aberrant double-stranded RNA sensing.
[Cell Reports] |
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| B-cell subsets in peripheral blood and tumor microenvironment were evaluated to determine myasthenia gravis (MG) severity in patients with thymoma-associated MG (TMG) and the distribution of B cells in type B TMG.
[Scientific Reports] |
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| Scientists selected 44 atopic dermatitis (AD) patients and 27 non-AD volunteers for the study. The results showed increased frequencies of both CLA+CD56bright and CLA+CD56dim NK cell populations in the peripheral blood, mainly in severe AD patients.
[Scientific Reports] |
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| The authors review the composition and sources of exosomes in the solid cancer immune microenvironment and further elaborate on the potential mechanisms and pathways by which exosomes influence immunotherapy for solid cancers.
[Cell Death & Disease] |
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| Acepodia announced that the US FDA has cleared the company’s investigational new drug application for ACE2016, an allogeneic gamma delta 2 (γδ2) T cell therapy for the treatment of epidermal growth factor receptor (EGFR)-expressing malignancies in patients with solid tumors.
[Acepodia Inc. (PR Newswire)] |
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| The DeGregorio Family Foundation has awarded $75,000 to David E. Avigan, MD, for the development of a personalized dendritic cell/organoid-based vaccine for the treatment of gastric cancer.
[DeGregorio Family Foundation (PR Newswire)] |
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| February 23 – 26, 2024
Washington, DC, United States |
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| | Cancer Research UK Manchester Institute – Manchester, England, United Kingdom |
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| | Dana-Farber – Boston, Massachusetts, United States |
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| | University of Minnesota – Minneapolis, Minnesota, United States |
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| | Cellistic – Mont-Saint-Guibert, Belgium |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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