| Vol. 12.05 – 13 February, 2024 |
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| Analysis of circulating NK cells in a longitudinal early-life cohort of children with atopic dermatitis (AD) revealed a progressive accumulation of NK cells with low expression of the activating receptor NKG2D. [Science Immunology] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed intranasal inoculation of 34 young adult, seronegative volunteers with a pre-Alpha severe acute respiratory syndrome coronavirus 2 strain. [Science Immunology] |
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| To investigate epigenetic and transcriptional alterations to the Alzheimer’s disease peripheral immune system, researchers used single-cell sequencing strategies, including assay for transposase-accessible chromatin and RNA sequencing. [Neuron] |
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| The authors developed a score integrating the binding affinity of neoantigens to human leukocyte antigen class I (HLA-I), as well as HLA-I allele divergence, termed the HLA tumor-Antigen Presentation Score. [Nature Communications] |
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| Investigators conducted an open-label study in virally induced acute respiratory distress syndrome caused by the severe acute respiratory syndrome-2 virus. [Nature Communications] |
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| Scientists established NR4A1 as a valid target for cancer immunotherapy and describeed a first-of-its-kind proteolysis-targeting chimera (PROTAC, named NR-V04) against NR4A1. [Journal Of Experimental Medicine] |
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| Researchers employed multi-omics analysis of 130 samples from 18 synchronous colorectal cancer liver metastasis patients integrated with external datasets to comprehensively evaluate the interaction between immune cells and epithelial-mesenchymal transition of tumor cells in liver metastasis. [Cancer Research] |
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| Investigators developed a cell membrane-targeting photosensitizer, TBzT-CNQi, which could generate 1O2, •OH, and O2•− via type I/II process to induce a high level of lipid peroxide for potent ferroptosis and photodynamic therapy. [Advanced Healthcare Materials] |
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| Scientists employed a flow cytometric assay to analyze histone acetylation at single-cell level in human T cells. [Clinical Epigenetics] |
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| Despite recent advances in frontline therapy for diffuse large B-cell lymphoma (DLBCL), at least a third of those diagnosed still will require second or further lines for relapsed or refractory disease. [Blood Cancer Journal] |
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| Universities must declare all their retractions and launch investigations into misconduct cases; a Nature analysis reveals that since 2021 there have been more than 17,000 Chinese co-authored retractions. [Nature News] |
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| February 24 – 25, 2024 Galveston, Texas, United States |
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| RMIT University – Melbourne, Australia |
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| Queens University Belfast – Belfast, Ireland, United Kingdom |
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| The Genomics Research Center, Academia Sinica – Taipei City, Taiwan |
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| University College London – London, England, United Kingdom |
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| Cancer Research UK Manchester Institute – Manchester, England, United Kingdom |
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