Human Immunology News Volume 12.05 | Feb 13 2024

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    2024-02-13 | HIN 12.05


    Human Immunology News by STEMCELL Technologies
    Vol. 12.05 – 13 February, 2024
    TOP STORY

    Progressive Accumulation of Hyperinflammatory NKG2Dlow NK Cells in Early Childhood Severe Atopic Dermatitis

    Analysis of circulating NK cells in a longitudinal early-life cohort of children with atopic dermatitis (AD) revealed a progressive accumulation of NK cells with low expression of the activating receptor NKG2D.
    [Science Immunology]

    Abstract
    Explore how immune cell isolation can be made easy
    PUBLICATIONSRanked by the impact factor of the journal

    Mucosal and Systemic Immune Correlates of Viral Control after SARS-CoV-2 Infection Challenge in Seronegative Adults

    Scientists performed intranasal inoculation of 34 young adult, seronegative volunteers with a pre-Alpha severe acute respiratory syndrome coronavirus 2 strain.
    [Science Immunology]

    Abstract

    Epigenetic Dysregulation in Alzheimer’s Disease Peripheral Immunity

    To investigate epigenetic and transcriptional alterations to the Alzheimer’s disease peripheral immune system, researchers used single-cell sequencing strategies, including assay for transposase-accessible chromatin and RNA sequencing.
    [Neuron]

    AbstractGraphical Abstract

    Assessment of Human Leukocyte Antigen-Based Neoantigen Presentation to Determine Pan-Cancer Response to Immunotherapy

    The authors developed a score integrating the binding affinity of neoantigens to human leukocyte antigen class I (HLA-I), as well as HLA-I allele divergence, termed the HLA tumor-Antigen Presentation Score.
    [Nature Communications]

    Full Article

    A Phase I/II Clinical Trial of Invariant Natural Killer T Cell Therapy in Moderate-Severe Acute Respiratory Distress Syndrome

    Investigators conducted an open-label study in virally induced acute respiratory distress syndrome caused by the severe acute respiratory syndrome-2 virus.
    [Nature Communications]

    Full ArticleGraphical Abstract

    PROTAC-Mediated NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy

    Scientists established NR4A1 as a valid target for cancer immunotherapy and describeed a first-of-its-kind proteolysis-targeting chimera (PROTAC, named NR-V04) against NR4A1.
    [Journal Of Experimental Medicine]

    Full Article
    Graphical
    Abstract

    Th17 Cells Secrete TWEAK to Trigger Epithelial-Mesenchymal Transition and Promote Colorectal Cancer Liver Metastasis

    Researchers employed multi-omics analysis of 130 samples from 18 synchronous colorectal cancer liver metastasis patients integrated with external datasets to comprehensively evaluate the interaction between immune cells and epithelial-mesenchymal transition of tumor cells in liver metastasis.
    [Cancer Research]

    Abstract

    Cell Membrane-Targeting Type I/II Photodynamic Therapy Combination with FSP1 Inhibition for Ferroptosis-Enhanced Photodynamic Immunotherapy

    Investigators developed a cell membrane-targeting photosensitizer, TBzT-CNQi, which could generate 1O2, •OH, and O2•− via type I/II process to induce a high level of lipid peroxide for potent ferroptosis and photodynamic therapy.
    [Advanced Healthcare Materials]

    Abstract

    Per-Cell Histone Acetylation Is Associated with Terminal Differentiation in Human T Cells

    Scientists employed a flow cytometric assay to analyze histone acetylation at single-cell level in human T cells.
    [Clinical Epigenetics]

    Full Article
    Fuel Your T Cell Therapy Development with High-Performance cGMP ImmunoCultâ„¢-XF
    REVIEWS

    Bispecific Antibodies and CAR-T Cells: Dueling Immunotherapies for Large B Cell Lymphomas

    Despite recent advances in frontline therapy for diffuse large B-cell lymphoma (DLBCL), at least a third of those diagnosed still will require second or further lines for relapsed or refractory disease.
    [Blood Cancer Journal]

    Abstract
    INDUSTRY AND POLICY NEWS

    China Conducts First Nationwide Review of Retractions and Research Misconduct

    Universities must declare all their retractions and launch investigations into misconduct cases; a Nature analysis reveals that since 2021 there have been more than 17,000 Chinese co-authored retractions.
    [Nature News]

    Editorial
    FEATURED EVENT

    2024 Biology of Acute Respiratory Infection Seminar GRC

    February 24 – 25, 2024
    Galveston, Texas, United States

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    JOB OPPORTUNITIES

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    RMIT University – Melbourne, Australia

    Research Fellow – Experimental Medicine

    Queens University Belfast – Belfast, Ireland, United Kingdom

    Tenure-Track Faculty – Metabolic Sciences

    The Genomics Research Center, Academia Sinica – Taipei City, Taiwan

    Postdoctoral Research Fellow – T Cell Retention in the Liver

    University College London – London, England, United Kingdom

    Postdoctoral Scientist – Skin Cancer and Aging

    Cancer Research UK Manchester Institute – Manchester, England, United Kingdom

    > See All Jobs

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