 | | Vol. 12.06 – 20 February, 2024 |
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| Scientists investigated 136 variables and identified smoking, cytomegalovirus latent infection and body mass index as major contributors to variability in cytokine response, with effects of comparable magnitudes with age, sex, and genetics.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To better understand immune cell surveillance and diverse immune evasion responses in tumor tissues, researchers comprehensively characterized the immune landscape of more than 1,000 tumors across ten different cancers using CPTAC pan-cancer proteogenomic data.
[Cell] |
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| Investigators conducted transcriptomic analyses and non-negative matrix factorization on 271 pre-treatment patient tumor samples from IMpower133 and identified four subsets with general concordance to previously reported small-cell lung cancer subtypes.
[Cancer Cell] |
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| Using single-cell sequencing and mouse models, researchers showed that CXCL13, highly expressed in tumor-infiltrating exhausted CD8+ T cells, induced CD4+ follicular helper T (TFH) cell infiltration, contributing to anti-tumor immunity.
[Cell Reports] |
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| The authors examined how Dickkopf-1 (DKK1) expression varied across different tumor and normal tissues. They investigated the association between DKK1 mRNA expression and clinical outcomes.
[Aging] |
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| Scientists constructed a large-scale population cohort and used the CyTOF to explore the changes of various immune cell subsets in peripheral blood of colorectal cancer.
[iScience] |
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| Investigators characterized a new patient with mycobacterial disease by genetic, immunological, and clinical means. Therapeutic decisions were taken on the basis of these findings.
[Journal Of Clinical Immunology] |
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| Researchers examined vaccine responses in relation to immune reconstitution and post hematopoietic cell transplantation (HCT) rituximab administration. Their single center retrospective study included 251 patients with hematological malignancies who received a CD34-selected HCT.
[Bone Marrow Transplantation] |
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| Scientists employed high-dimensional mass cytometry to reveal the immunophenotypic characteristics of peripheral blood immune cells at various Suzuki stages, offering insights into the progression of Moyamoya disease.
[Immunologic Research] |
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| The authors discuss the distinct functions of LAG-3, TIM-3, and TIGIT, including their contributions to the regulation of immune cells beyond T cells, their roles in disease, and the implications for their targeting in the clinic.
[Immunity] |
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| Scientists summarize the current understanding of the sources and fates of resident central nervous system (CNS)-associated macrophages in health and disease, and the role of the microenvironment in influencing their maintenance and function.
[Acta Neuropathologica] |
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| The US FDA is several weeks late in issuing guidance on how and when drug and device companies must submit diversity action plans for clinical trial research.
[Regulatory Affairs Professionals Society] |
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| March 5 – 7, 2024
Boston, Massachusetts, United States |
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| | Queen’s University Belfast – Belfast, Ireland, United Kingdom |
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| | Maynooth University – Maynooth, Ireland, United Kingdom |
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| | Foundation for Liver Research – London, England, United Kingdom |
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| | King’s College Hospital – London, England, United Kingdom |
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| | UC Davis – Davis, California, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
