 | | Vol. 12.07 – 27 February, 2024 |
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| Investigators evaluated the effect of human leukocyte antigen heterozygosity on lung cancer risk, leveraging genetic and longitudinal clinical data from the UK Biobank and FinnGen together with multimodal genomic analyses of nonmalignant and lung tumor samples.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In a series of clinical studies on male and female participants that involved graded amounts of protein ingestion together with detailed plasma amino acid analysis and human monocyte/macrophage experiments, the authors identified leucine as the key activator of mTOR signaling in macrophages.
[Nature Metabolism] |
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| Researchers reported that tumor-associated monocytes were highly correlated with the accumulation of CD8+ memory T cells in human cancers.
[Advanced Science] |
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| Using single-cell transcriptomic and spatial multiplex immunofluorescence analyses, scientists showed that PD-L1+ tumor-associated macrophages were mature and immunostimulatory with spatial preference to T cells.
[Cell Reports Medicine] |
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| Researchers showed that constitutive expression of Δ133p53α potentiated the anti-tumor activity of CD19-directed CAR T cells and limits dysfunction under conditions of high tumor burden and metabolic stress.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators analyzed serum samples from 90 humans and 72 rhesus macaques for the abundance and activity of the complement system components.
[mBio] |
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| Frozen T cell-free cord blood mononuclear cells were cultured with recombinant human interleukin (rhIL)-18 and rhIL-2 in anti-NKp46 and anti-CD16 antibody immobilization settings.
[Regenerative Therapy] |
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| Three Luminex xMAP assays and two ELLA microfluidic cartridges were used to screen 28 immune-related biomarkers in 38 paired serum and citrate-theophylline-adenosine-dipyridamole plasma samples.
[International Journal Of Biological Markers] |
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| Researchers described a Chinese patient with infantile-onset diabetes and multiorgan autoimmunity. The patient presented with early-onset type 1 diabetes and autoimmune hypothyroidism at seven months.
[Molecular Genetics & Genomic Medicine] |
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| The authors explore in detail the complexity of NK cell biology in humans and highlight the role of these cells in cancer immunity.
[Nature] |
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| Along with the introduction of key technical advancements in immunopeptidomics, the potential and further directions of immunopeptidomics are reviewed from the perspective of cancer immunotherapy.
[Cancer Science] |
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| ENPICOM announced a collaboration with Erasmus Medical Center. This partnership aims to identify and develop nanobodies against cancer by utilizing ENPICOM’s immune repertoire data analysis services and software solutions.
[ENPICOM (Life Science Newswire)] |
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| March 13 – 16, 2024
Davos, Switzerland |
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| | Leeds Teaching Hospital – Leeds, England, United Kingdomn |
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| | Cedars Sinai Medical Center – Los Angeles, California, United States |
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| | Queen’s University Belfast – Belfast, Ireland, United Kingdom |
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| | Maynooth University – Maynooth, Ireland, United Kingdom |
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| | Foundation for Liver Research – London, England, United Kingdom |
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Cancer Stem Cell News
Cell Therapy News
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