 | | Vol. 12.08 – 5 March, 2024 |
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| Investigators found that a high baseline of intratumoural macrophages and regulatory T cells was associated with better outcomes in patients treated with atezolizumab plus tiragolumab but not with atezolizumab alone.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers assessed 214 individuals infected with SARS-CoV-2, with varying disease severity, for one year from COVID-19 symptom onset to determine the early correlates of post-acute sequelae.
[Nature Immunology] |
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| Scientists developed a platform that combined bioinformatic analysis of tumor exomes and transcriptional data with functional testing of autologous peripheral blood mononuclear cells to simultaneously identify and validate neoantigens recognized by naturally primed CD4+ and CD8+ T cell responses.
[Science Translational Medicine] |
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| The authors showed that unlike the variant found exclusively in healthy controls, SH2B3 rare variants found in lupus patients were predominantly hypomorphic alleles, failing to suppress IFNGR signaling via JAK2-STAT1.
[Journal Of Experimental Medicine] |
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| Investigators identified a distinct mesenchymal-like population of endothelial cells that formed an immunosuppressive vascular niche in glioblastoma.
[Science Advances] |
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| The authors revealed that chronic stress inhibited the recruitment of tumor-associated macrophages and other immune cells, and decreased the level of proinflammatory cytokines in gliomas, leading to an immunosuppressive microenvironment and glioma progression.
[Cancer Immunology Research] |
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| Scientists investigated the effects of retinoic acid-loaded liposomes on human dendritic cell (DC) phenotype and function, including DC-driven T-cell development, both during the generation of monocyte-derived DCs (moDCs) as well as by priming immature moDCs.
[European Journal of Immunology] |
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| The proportion of group 2 innate lymphoid cells (ILC2s) originating from various tissue sources were quantified through flow cytometry, along with the determination of CD4+ T cell and CD8+ T cell percentages.
[Cancer Immunology Immunotherapy] |
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| Blood from 17 patients with polyarticular juvenile idiopathic arthritis was collected at initial diagnosis and again if remission was achieved. Pediatric healthy controls were also collected.
[Pediatric Rheumatology] |
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| Investigators discuss natural killer (NK) cell function and the alterations in the frequency of these cells in human T cell leukemia virus type 1 (HTLV-1) infection.
[Molecular Neurobiology] |
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| The University of Alabama at Birmingham’s Immunology Institute Pilot Project program has selected three research projects to award funding during its inaugural year.
[University of Alabama at Birmingham] |
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| March 21 – 23, 2024
Tokyo, Japan |
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| | Foundation for Liver Research – London, England, United Kingdom |
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| | Georg-Speyer-Haus – Frankfurt, Germany |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | Foundation for Liver Research – London, England, United Kingdom |
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| | UC Davis – Davis, California, United States |
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