 | | Vol. 12.09 – 12 March, 2024 |
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| Researchers unveiled the histone demethylase PHF8 as a direct initiator and regulator of cell-intrinsic immune response in acute myeloid leukemia. Site-specific phosphorylation of PHF8 orchestrated epigenetic changes that upregulate cytosolic RNA sensors.
[Blood] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators observed that approximately 1–5% of CD4+ T cells from the blood of people living with HIV-1 exhibited over-duplicated centrioles, suggesting that centrosome amplification underlied the development of HIV-1-associated cancers by driving aneuploidy.
[Nature Communications] |
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| Researchers identified neutrophils as an important source of IL-26 and point to IL-26 as the key link between neutrophils and a self-sustaining autoinflammation loop in pustular psoriasis.
[Journal Of Experimental Medicine] |
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| Scientists generated a single-cell RNA sequencing map to decipher the immune dynamics during human lung adenocarcinoma development.
[Cell Reports Medicine] |
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| Using gain-of-function genetic screens, researchers profiled axon guidance proteins on human T cells and their cognate ligands and identified fibronectin leucine-rich transmembrane protein 3 (FLRT3) as a ligand that inhibits T cell activity.
[Science Advances] |
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| Investigators compared the immune-cell compartment of Crohn’s disease (CD) fistula to inflammatory CD colitis using imaging mass cytometry and immunofluorescence.
[Journal Of Crohns And Colitis] |
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| Researchers found that an increased copy number of MYB was associated with higher MYB expression levels, and might be associated with inferior event-free survival of pediatric T-lineage acute lymphoblastic leukemia patients.
[Hemasphere] |
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| The authors assessed the safety of sub-urothelial injection of durvalumab and examine the impact on tissue and circulating immune cell populations.
[BJU International] |
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| Scientists investigated whether the expression of CD27−CD38+ in interferon (IFN)-γ+CD4+ T cells stimulated by the specific antigen early secreted antigenic target-6/culture filter protein-10 could be a potential new therapeutic evaluation indicator for anti-tuberculosis treatment.
[European Journal Of Medical Research] |
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| Medline, Embase, and Cochrane databases were searched from inception to December 2023. Screening, data extraction, and quality appraisal were done by two independent reviewers.
[BMC Medicine] |
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| Scientists discuss the molecular mechanisms for suppression of the MHC class I pathway and clinical implications for COVID-19.
[Bioessays] |
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| Monte Rosa Therapeutics, Inc. announced a novel development candidate, MRT-8102. MRT-8102 is expected to be developed for the treatment of inflammatory diseases driven by interleukin-1β and the NLRP3 inflammasome, which are critical elements of the inflammatory process.
[Monte Rosa Therapeutics, Inc.] |
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| April 7 – 10, 2024
San Diego, California, United States |
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| | University of Denmark – Lyngby, Denmark |
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| | Foundation for Liver Research – London, England, United Kingdom |
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| | Georg-Speyer-Haus – Frankfurt, Germany |
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| | Indiana University School of Medicine – Indianapolis, Indiana, United States |
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| | Foundation for Liver Research – London, England, United Kingdom |
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