 | | Vol. 12.10 – 19 March, 2024 |
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| Researchers showed, through studies in mouse models lacking antibodies but maintaining functional B cells and lymphoid organs, that immunity conferred by prior infection or mRNA vaccination could protect against SARS-CoV-2 challenge independently of antibodies.
[Nature Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators found that human cells were able to up-regulate HLA-DR and co-stimulatory molecules; were able to process protein antigen into fragments recognized by T cells; could enter lymph node T cell zones; and, in vitro, were able to present antigen to memory T cells, inducing proliferation and cytokine production.
[Blood] |
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| Scientists highlighted the role of stromal tumor-infiltrating lymphocytes in patient selection/stratification for neo/adjuvant escalation and de-escalation strategies.
[Clinical Cancer Research] |
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| Researchers underscored the pivotal role of adipose stem cells in regulating T cell accumulation in white adipose tissue during the early phases of obesity, emphasizing their importance in modulating adaptive immunity in obesity-induced adipose inflammation.
[Cell Reports] |
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| A multicenter study of HIV-negative individuals with T. marneffei infection was conducted between September 2018 and 2020. Patients were divided into anti-interferon-γ autoantibody (AIGA)-positive and AIGA-negative groups according to the AIGA titer and neutralizing activity.
[Microbiology Spectrum] |
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| Researchers described that cancer cell-neutrophil signaling circuitry provoked neutrophil-derived transmembrane TNF-TNFR2 interactions that dictated inflammatory polarization in cancer-associated fibroblasts and T cell dysfunction – two hallmarks of therapeutic resistance.
[Oncoimmunology] |
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| Scientists investigated the expression and regulation of human leukocyte antigen-II in human glioblastoma samples and the correlation with lymphocyte-activation gene 3 (LAG-3)+CD4+ T cell infiltration.
[Cancer Science] |
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| Raman spectroscopy was applied to trace lymphocytes activation following contact with the Epstein–Barr virus of the herpesvirus family. The biomarker of cell activation was found to be the 520 cm−1 band, indicating the formation of immunoglobulins.
[Scientific Reports] |
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| Researchers investigated the transcriptome of human bronchial epithelial cells in response to serum from patients with different degrees of inflammation. Serum from 19 COVID-19 patients obtained from the Hannover Unified Biobank was used.
[Lung] |
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The authors review studies in which multiple blood-based biomarkers encompassing circulating soluble analytes, immune cell subsets, and circulating tumor cells have shown promising associations with the clinical response of non-small cell lung cancer patients to immune checkpoint inhibitors therapy.
[Journal Of Experimental & Clinical Cancer Research] |
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| TaiMed Biologics signed an Exclusive License and Distribution Agreement with AcedrA BioPharmaceuticals to satisfy the unmet medical needs, under which AcedrA will register, promote, and commercialize Trogarzo® in the MENA region.
[TaiMed Biologics (Globe Newswire)] |
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| April 9 – 12, 2024
Fairmont Banff Springs, Alberta, Canada |
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| | University of Oslo – Oslo, Norway |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | University of Montpellier – Montpellier, France |
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| | University of Denmark – Lyngby, Denmark |
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| | Foundation for Liver Research – London, England, United Kingdom |
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