 | | Vol. 12.11 – 26 March, 2024 |
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| By using IgG4-RD patient peripheral blood mononuclear cells (PBMCs), IgG4-RD cell lines, and Usp25 knockout mice, investigators showed that ubiquitin-specific protease 25 (USP25) engaged in multiple pathways to regulate fibrotic and inflammatory pathways that are characteristic to IgG4-RD.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers designed a highly multiplexed imaging mass cytometry panel to simultaneously quantify 31 biomarkers from 13 patients with relapsed/refractory DLBCL who received CAR19/22 T cell therapy.
[Molecular Therapy] |
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| NOUS-PEV is a vector-based personalized vaccine, expressing 60 nAgs, and consisted of priming with a non-human Great Ape Adenoviral vector. Investigators reported data from a Phase Ib trial of NOUS-PEV in combination with pembrolizuma in treatment naïve metastatic melanoma patients.
[Clinical Cancer Research] |
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| Researchers used systems biology approaches including proteomics, transcriptomics, and mass cytometry to define the circulating proteome and circulating immune cell phenotypes in subjects with COVID-19.
[Arteriosclerosis Thrombosis And Vascular Biology] |
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| Scientists showed that type III interferon (IFN-λ) was highly upregulated during human metapneumovirus infection in vitro in human and mouse airway epithelial cells and in vivo in mice. They found through several immunological and molecular assays that type II alveolar cells are the primary producers of IFN-λ.
[mBio] |
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| Investigators improved their understanding of smallpox vaccination-mediated cross-reactivity to other orthopox viruses, and the long-lasting durability of childhood smallpox vaccination-mediated immune responses including in people living with HIV.
[Journal Of Infectious Diseases] |
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| Scientists sought to enhance the in vivo longevity of CAR-Vδ2 T cells by modulating ex vivo manufacturing conditions and selecting an optimal CAR costimulatory domain.
[Cytotherapy] |
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| To investigate the effect of type I IFN on the inflammasome, the authors treated human monocyte-derived macrophages with IFN-α and observed an increase in CASP1 and GSDMD mRNA levels over time, whereas IL1B and NLRP3 were not directly correlated to IFN-α exposure time.
[Life Science Alliance] |
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| Researchers evaluated the prevalence of apical periodontitis in patients suffering from autoimmune liver diseases, in treatment with the immune-suppressants glucocorticoids, azathioprine, and/or ursodeoxycholic acid.
[Journal Of Endodontics] |
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| The authors discuss the use of per- and polyfluoroalkyl substances (PFAS) immunotoxicity data in regulatory and clinical decision-making contexts and question whether recent efforts adequately account for PFAS immunotoxicity in public health decision-making.
[Current Environmental Health Reports] |
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| Eledon Pharmaceuticals, Inc. announced that the company’s investigational anti-CD40L antibody, was used as a component of the immunosuppressive treatment regimen following the first-ever transplant of a kidney from a genetically modified pig to a human.
[Eledon Pharmaceuticals, Inc.] |
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| April 17 – 20, 2024
Rotterdam, Netherlands |
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| | Wageningen University and Research Center – Wageningen, Netherlands |
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| | University of Manitoba – Winnipeg City, Manitoba, Canada |
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| | NYU Langone Health – New York City, New York, United States |
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| | Universitätsklinikum Köln – Cologne, Germany |
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| | University of Oslo – Oslo, Norway |
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