 | | Vol. 12.12 – 2 April, 2024 |
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| Scientists demonstrated a protective role for autophagy in HIV-1 disease pathogenesis. Targeted analysis of genetic variation in core autophagy gene ATG16L1 revealed the previously unidentified rs6861 polymorphism, which correlated clinically with improved survival of untreated HIV-1-infected individuals.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators applied CAT-S to diverse cell cultures, dissociated mouse tissues as well as primary T cells from human blood, portraying the native-state mitochondrial proteomic characteristics, and unveiled hidden mitochondrial proteins.
[Nature Communications] |
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| Scientists reported seven patients aged 5–61 years from five families of four ancestries with autosomal recessive CD4 deficiency and a range of infections, including recalcitrant warts and Whipple’s disease.
[Journal Of Experimental Medicine] |
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| An immunomagnetic exosomal polymerase chain reaction platform was developed using DNA-conjugated antibodies for the rapid detection of amyloid-β and phosphorylated tau in clinical blood exosomes.
[Science Advances] |
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| Researchers established a gut epithelium-microbe-immune microphysiological system to maintain the long-term continuous co-culture of Faecalibacterium prausnitzii/Faecalibacterium duncaniae with colonic epithelium, antigen-presenting cells, and CD4+ naive T cells circulating underneath the colonic epithelium.
[NPJ Biofilms And Microbiomes] |
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| Investigators found that the presence of viral infection was evidently associated with improved outcomes in cancer patients undergoing immune checkpoint inhibitors, particularly in cases of HBV/HCV and HPV infections.
[Cancer Immunology Immunotherapy] |
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| Human anti-B7H3 single-chain antibodies were isolated and screened from the fully human phage immune library with B7H3 as the target. The antibodies screened from a fully human phage library had low immunogenicity and high affinity, which was more beneficial for clinical application.
[International Immunopharmacology] |
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| Investigators explored immune cell release, particularly tissue-resident lymphocytes, during donor kidney machine perfusion and its correlation with injury markers.
[Transplantation] |
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| Persons with HIV on antiretroviral therapy were enrolled in the clinical trial. Blood was collected at baseline and days 2,4,7,14, and 30 postimmunizations. Expression of immunological markers on T cell subsets were measured by flow cytometry.
[Aids] |
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| The authors coalesce existing knowledge on the human archaeome, a less-studied yet critical non-bacterial component of the human microbiome, with a focus on its interaction with the immune system.
[FEBS Journal] |
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| The randomized, controlled, open-label study is designed to quantify the clinical benefit of maintenance therapy with GRANITE in combination with immune checkpoint blockade in addition to fluoropyrimidine/bevacizumab versus fluoropyrimidine/bevacizumab alone.
[Gritstone bio, Inc.] |
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| April 22 – 25, 2024
Banff, Alberta, Canada |
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| | Johns Hopkins School of Medicine – Saint Petersburg, Florida, United States |
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| | Cellistic – Mont-Saint-Guibert, Belgium |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Colorado – Aurora, Colorado, United States |
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| | University of Oslo – Oslo, Norway |
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