 | | Vol. 12.13 – 9 April, 2024 |
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| The authors presented results from a single-arm, open-label, Phase I/II study of a DNA plasmid PTCV encoding up to 40 neoantigens coadministered with plasmid-encoded interleukin-12 plus pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with a multityrosine kinase inhibitor.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| To identify cellular determinants of prime editing, investigators developed scalable prime editing reporters and performed genome-scale CRISPR-interference screens.
[Nature] |
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| Using mass spectrometry-based targeted lipidomics, researchers characterized the lipid landscape of human and mouse immune cells and showed that immune cells had unique lipidomic signatures and that processes such as activation, maturation, and development impact immune cell lipid composition.
[Nature Cell Biology] |
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| The authors characterized the immunogenomic profile and spatial architecture of the tumor microenvironment in adolescent and young adult (AYA) and older adult patients with melanoma, to determine the AYA-specific features associated with immune checkpoint inhibitors treatment outcomes.
[Nature Communications] |
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| Scientists focused on the effects of marine bacteria and endotoxins in sea spray aerosols on several receptors and transcription factors known to play a key role in the human innate immune system.
[Science Of The Total Environment] |
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| Researchers created a single-cell RNA-sequencing dataset of HBV immune responses in patients to contribute to a better understanding of the dysregulated immunity.
[Scientific Data] |
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| Investigators compared biomarker levels between prurigo nodularis (PN) and HCs, among PN patients based on absolute eosinophil count, and across racial groups in PN.
[Scientific Reports] |
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| Scientists analyzed whole blood data obtained from patients with sepsis and control samples sourced from three datasets. Commonly dysregulated immune-related genes among these three datasets were identified.
[Heliyon] |
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| Scientists synthesize current knowledge on immune-mediated necrotizing myopathy emphasizing its distinct clinical features and challenging management. The evolving understanding of IMNM underscores the need for a comprehensive diagnostic approach that utilizes a growing range of modalities.
[Current Neurology And Neuroscience Reports] |
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| The Federation of American Societies for Experimental Biology (FASEB) announced the recipients of its 2024 Excellence in Science Awards. An experimental pathologist and immunologist, Pilar Alcaide of Tufts University School of Medicine is the recipient of the Mid-Career Investigator Award.
[FASEB] |
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| Yale School of Medicine annanounced announce that two Immunobiology PhD students, Tomomi Yoshida and Sarah Ohashi were recently awarded the prestigious Ruth L. Kirschstein Predoctoral Individual National Research Service Awards from the National Institutes of Health.
[Yale School of Medicine] |
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| May 6 – 9, 2024
Killarney, Ireland |
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| | Yale University – New Haven, Connecticut, United States |
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| | Johns Hopkins School of Medicine – Saint Petersburg, Florida, United States |
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| | Cellistic – Mont-Saint-Guibert, Belgium |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Colorado – Aurora, Colorado, United States |
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