C-Type Lectin-Like Receptor LOX-1 Promotes Dendritic Cell-Mediated Class-Switched B Cell Responses The authors report that lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expressed on dendritic cells and B cells promotes humoral responses. On B cells LOX-1 signaling upregulated CCR7, promoting cellular migration toward lymphoid tissues. [Immunity] Abstract Human TLR10 Is an Anti-Inflammatory Pattern-Recognition Receptor The authors demonstrate that Toll-like receptor (TLR)10 is a modulatory receptor with mainly inhibitory effects. Blocking TLR10 by antagonistic antibodies enhanced proinflammatory cytokine production, including IL-1β, specifically after exposure to TLR2 ligands. [Proc Natl Acad Sci USA] Abstract Central Domain of IL-33 Is Cleaved by Mast Cell Proteases for Potent Activation of Group-2 Innate Lymphoid Cells Researchers investigated the role of mast cells known to interact with group-2 innate lymphoid cells (ILC2s) in vivo. They found that serine proteases secreted by activated mast cells generate mature forms of interleukin-33 (IL-33) with potent activity on ILC2s. [Proc Natl Acad Sci USA] Abstract MHC Class I Loss Is a Frequent Mechanism of Immune Escape in Papillary Thyroid Cancer that Is Reversed by Interferon and Selumetinib Treatment In Vitro Researchers evaluated major histocompatibility complex (MHC) class I expression on papillary thyroid cancer (PTC) and analyzed changes in MHC expression and associated immune activation with current and experimental treatments for thyroid cancer using in vitro PTC cell lines. Functional changes in antigenicity were assessed by co-culture of allogeneic donor peripheral blood leukocytes with pre-treated or untreated PTC cell lines and measurement of T cell activation and cytokine production. [Clin Cancer Res] Abstract First-in-Man Study of Western Reserve Strain Oncolytic Vaccinia Virus: Safety, Systemic Spread and Anti-Tumor Activity Investigators performed the first-in-human Phase I, intratumoral dose escalation clinical trial of the Western Reserve strain of vaccinia virus engineered for tumor selectivity through two targeted gene deletions (vvDD) in 16 patients with advanced solid tumors. In addition to safety, they evaluated signs of vvDD replication and spread to distant tumors, pharmacokinetics and pharmacodynamics, clinical and immune responses to vvDD. [Mol Ther] Abstract Coordinated Regulation of NK Receptor Expression in the Maturing Human Immune System Using mass cytometry, scientists found that natural killer cell receptor (NKR) expression patterns distinguish cell lineages in human peripheral blood. Mature NK and CD8+ T cell populations show increased diversity of NKR surface expression patterns, but with distinct determinants. [J Immunol] Abstract Genetic Polymorphisms and Tissue Expression of Interleukin-22 Associated with Risk and Therapeutic Response of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma Investigators explored the genetic predisposition to mucosa-associated lymphoid tissue lymphoma and its clinical implication. In vitro experiments demonstrate that co-culturing peripheral mononuclear cells or CD4+ T cells with Helicobacter pylori stimulated the secretion of interleukin-22 (IL-22), and that IL-22 induced the expression of antimicrobial proteins, RegIIIα and lipocalin-2, in gastric epithelial cells. [Blood Cancer J] Full Article Cellular Immunologic Responses to Cochlear Implantation in the Human Histologic evidence of a foreign body reaction has been described in temporal bones in patients who in life had undergone cochlear implantation. The cellular immune response was characterized using immunohistochemical stains for B-cell lymphocytes, T-cell lymphocytes, and macrophages. [Hear Res] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News and Immune Regulation News! |